21581-45-3

Basic information

• Product Name: 3,4-DICHLOROPHENETHYLAMINE
• Synonyms: TIMTEC-BB SBB003664;RARECHEM AL BW 0053;4-(2-AMINOETHYL)-1,2-DICHLOROBENZENE;3,4-DICHLOROPHENETHYLAMINE;2-(3,4-DICHLOROPHENYL)ETHYLAMINE;1-AMINO-2-(3,4-DICHLOROPHENYL)ETHANE;3,4-DICHLOROPHENETHYLAMINE 99%;3,4-Dichlorophenethylamine ,99%
• CAS NO: 21581-45-3
• Molecular Formula: C₈H₉Cl₂N
• Molecular Weight: 190.07
• Product Categories: Amines;C8;Nitrogen Compounds
• Mol File: 21581-45-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 280 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 1.268 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00753mmHg at 25°C
• Refractive Index: n20/D 1.5670(lit.)
• PKA: 9.30±0.10(Predicted)
• CAS DataBase Reference: 3,4-DICHLOROPHENETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DICHLOROPHENETHYLAMINE(21581-45-3)
• EPA Substance Registry System: 3,4-DICHLOROPHENETHYLAMINE(21581-45-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38
• Safety Statements: 26
• RIDADR: 2735
• WGK Germany: 3
• HazardClass: IRRITANT, TOXIC
• Hazardous Substances Data: 21581-45-3(Hazardous Substances Data)

Usage

Description

3,4-Dichlorophenethylamine is an organic compound derived from the reaction of 3,4-dichlorophenylacetonitrile with a suspension of lithium aluminum hydride (LiAlH4) in dry diethyl ether under a nitrogen atmosphere. It is characterized by its clear colorless to light yellow liquid appearance.

Uses

Used in Pharmaceutical Synthesis:
3,4-Dichlorophenethylamine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in the Synthesis of N-(3′,4′-dichlorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol:
3,4-Dichlorophenethylamine is used as a starting material for the synthesis of N-(3′,4′-dichlorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol, a complex organic molecule with potential applications in the pharmaceutical industry.
Used in the Synthesis of 2-[2-(3,4-dichlorophenyl)ethylamino]-1-pyridin-3-ylethanol:
3,4-Dichlorophenethylamine is also utilized in the synthesis of 2-[2-(3,4-dichlorophenyl)ethylamino]-1-pyridin-3-ylethanol, another complex organic molecule that may have applications in the development of new drugs and pharmaceuticals.

InChI:InChI=1/C8H9Cl2N/c9-7-2-1-6(3-4-11)5-8(7)10/h1-2,5H,3-4,11H2/p+1

Upstream product

• 3218-49-3 3,4-dichloro-benzeneacetonitrile 
• 426826-80-4 [2-(3,4-dichlorophenyl)ethyl]carbamic acid tert-butyl ester 
• 792909-20-7 [2-(3,4-dichlorophenyl)ethyl]carbamic acid phenyl ester 
• 37630-23-2 1,2-dichloro-4-(2-nitrovinyl)benzene 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 37630-23-2 (E)-1,2-dichloro-4-(2-nitrovinyl)benzene 

Downstream Products

• 101273-28-3 (3,4-dichloro-phenyl)-acetic acid-(3,4-dichloro-phenethylamide) 
• 100871-55-4 isonicotinic acid-(3,4-dichloro-phenethylamide) 
• 35364-79-5 2-(3,4-dichlorophenyl)ethanol 
• 107921-49-3 (3,4-dichloro-phenethylamino)-acetaldehyde diethylacetal 
• 26502-00-1 3,5-bis-(3,4-dichloro-phenethyl)-[1,3,5]thiadiazinane-2-thione 
• 23751-63-5 N.N'-Bis-<3.4-dichlor-phenaethyl>-thioharnstoff 
• 47168-30-9 2-[2-(3,4-Dichloro-phenyl)-ethylamino]-1-(4-fluoro-phenyl)-ethanol 
• 92908-03-7 N-<2-(3,4-Dichlor-phenyl)-aethyl>-3,4-dichlor-phenylacetamidin 
• 95822-62-1 N.N'.N''-Tris-<3.4-dichlor-phenaethyl>-guanidin 
• 47168-29-6 N-<2-(4-Chlorphenyl)-2-hydroxyethyl>-3,4-dichlorphenylethylamin 
• 4780-71-6 3-(3,4-dichloro-phenethyl)-5-(2-hydroxy-ethyl)-[1,3,5]thiadiazinane-2-thione 
• 6585-06-4 3-(3,4-dichloro-phenethyl)-5-(2-diethylamino-ethyl)-[1,3,5]thiadiazinane-2-thione 
• 26324-20-9 5-allyl-3-(3,4-dichloro-phenethyl)-[1,3,5]thiadiazinane-2-thione 
• 26328-88-1 [5-(3,4-dichloro-phenethyl)-6-thioxo-[1,3,5]thiadiazinan-3-yl]-acetic acid 

Relevant articles and documents

Benzo-aza-alkyl aryl piperazine derivative and applications in preparation of drugs

The invention discloses a benzo-aza-alkyl aryl piperazine derivative and applications in preparation of drugs. The derivative shows the effect on central nervous systems, especially on the double highaffinity activity of a 5-HT acceptor and a Sigma-1 acceptor. Various physiological and pharmacological effects are brought into play in the body; and the compound can be used as a pharmaceuticalactive substance, especially used for anti-depression, anti-anxiety, anti-bipolar affective disorder and anti-neuropathic pain, and can also be used as an intermediate to prepare other pharmaceuticalactive compounds. The compound is fast in effect and small in toxic and side effect, and can meet demands of clinical applications; and the compound is a compound or a free base or salt thereof havingthe following structural formula (IV). The structure of the compound or the free base or salt thereof is shown as the structural formula (IV).

17a-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.

17α-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.