216011-55-1Relevant articles and documents
Trypanocidal labdane diterpenoids from the seeds of Aframomum aulacocarpos (Zingiberaceae)
Sob, Sylvain Valère T.,Tane, Pierre,Ngadjui, Bonaventure T.,Connolly, Joseph D.,Ma, Dawei
, p. 8993 - 8998 (2007)
Two novel labdane type diterpenoids, 8β(17)-epoxy-14,15,16-trihydroxylabd-12(E)-ene (aulacocarpin C) and 15,16-epoxy-14ξ,16ξ-dimethoxylabda-8(17),12-(E)-diene (aulacocarpin D) together with the known aulacocarpin A and B; 14,15-epoxy-8(17),12(E)-labdadien-16-al, coronarin E, and 15,16-epoxy-12β-hydroxy-labda-8(17)-13(16),14-triene were isolated from the seeds of Aframomum aulacocarpos. To the best of our knowledge, the last compound was isolated from a natural source for the first time. Acid hydrolysis of aulacocarpin D led to another new labdane type diterpenoid, 15,16-epoxy-12β-methoxylabda-8(17)-13(16),14-triene. The structures of all compounds were established on the basis of their spectroscopic data. These new compounds exhibit moderate trypanocidal activity.
Facile access to labdane-type diterpenes: Synthesis of coronarin C, zerumin B, labda-8(17), 13(14)-dien-15,16-olide and derivatives from (+)-manool
Villamizar, Jose E.,Juncosa, Jose,Pittelaud, Jean,Hernandez, Madeleyn,Canudas, Nieves,Tropper, Eleonora,Salazar, Franklin,Fuentes, Juan
, p. 342 - 346 (2007)
A practical method for the synthesis of optically active labdane-type diterpenes from (+)-manool 8, is described. We prepared the natural labdane-type diterpene 5 via key intermediate peroxide 9 and coronarin C 1, compound 8 and zerumin B 6 via a furan photosensitised oxygenation reactions.
Synthesis of chinensines A-E
Margaros, Ioannis,Vassilikogiannakis, Georgios
, p. 4826 - 4831 (2008/02/05)
(Chemical Equation Presented) Short and efficient syntheses of coronarin E (4) and chinensines A-E (5-9) have been accomplished. The use of two different types of reaction of singlet oxygen (1O2) lies at the heart of the synthetic st