21814-48-2

Basic information

• Product Name: 1-CHLORO-7-METHOXY-4-NITRO-9,10-DIHYDROACRIDIN-9-ONE
• Synonyms: 1-CHLORO-7-METHOXY-4-NITRO-9,10-DIHYDROACRIDIN-9-ONE
• CAS NO: 21814-48-2
• Molecular Formula: C14H9ClN2O4
• Molecular Weight: 304.69
• Mol File: 21814-48-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-CHLORO-7-METHOXY-4-NITRO-9,10-DIHYDROACRIDIN-9-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-7-METHOXY-4-NITRO-9,10-DIHYDROACRIDIN-9-ONE(21814-48-2)
• EPA Substance Registry System: 1-CHLORO-7-METHOXY-4-NITRO-9,10-DIHYDROACRIDIN-9-ONE(21814-48-2)

Safety Data

• Hazardous Substances Data: 21814-48-2(Hazardous Substances Data)

Upstream product

• 55776-09-5 6-chloro-2-<(4-methoxyphenyl)amino>-3-nitrobenzoic acid 
• 55775-97-8 2,6-dichloro-3-nitrobenzoic acid 
• 104-94-9 4-methoxy-aniline 
• 50-30-6 2,6-dichlorobenzoic acid 

Downstream Products

• 99008-57-8 9-methoxy-N,N-dimethyl-5-nitropyrazolo[3,4,5-kl]acridine-2(6H)-ethanamine 
• 99008-55-6 N,N-diethyl-9-methoxy-5-nitropyrazolo<3,4,5-kl>acridine-2(6H)-ethanamine 
• 99009-20-8 Pyrazoloacridine 
• 134039-82-0 9-amino-7-methoxy-4-nitro-1-phenoxyacridine 
• 134039-84-2 1-chloro-7-methoxy-4-nitro-9-phenoxyacridine 
• 99009-21-9 Pyrazoloacridine methanesulfonate 

Relevant articles and documents

Structure-activity relationship of novel acridone derivatives as antiproliferative agents

Unlike other DNA topoisomerase II (topo II) inhibitors, our recently identified acridone derivative E17 exerted strong cytotoxic activity by inhibiting topo II without causing topo II degradation and DNA damage, which promoted us to explore more analogues

Triazoloacridin-6-ones as novel inhibitors of the quinone oxidoreductases NQO1 and NQO2

A range of triazoloacridin-6-ones functionalized at C5 and C8 have been synthesized and evaluated for ability to inhibit NQO1 and NQO2. The compounds were computationally docked into the active site of NQO1 and NQO2, and calculated binding affinities were

Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them

Substituted 1-amino-4-nitroacridinones, their method of manufacture, pharmaceutical compositions and their use as antibacterial and antitumor agents are herein described.