21816-82-0Relevant articles and documents
Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles
Fajkusova, Dagmar,Pesko, Matus,Keltosova, Stanislava,Guo, Jiahui,Oktabec, Zbynek,Vejsova, Marcela,Kollar, Peter,Coffey, Aidan,Csollei, Jozef,Kralova, Katarina,Jampilek, Josef
, p. 7059 - 7068 (2012)
In this study, a series of N-substituted 2-aminobenzothiazoles was prepared according to a recently developed method. Twelve compounds were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia
An aerobic oxidative coupling approach for the synthesis of N-substituted 2-aminobenzothiazole derivatives using iron catalyst
Kumar, N. V. Anil,Kamath, Shailesha,Gaonkar, Santosh L.,Shetty, Nitinkumar S.
, p. 1697 - 1702 (2016)
A facile and convenient method was developed for the formation of novel N substituted 2-aminobenzothiazoles via an iron-catalysed condensation of 2-aminobenzothizole with different amines. This method is applicable for a wide range of aliphatic, aromatic and heterocyclic amines furnishing moderate yields of the corresponding products and thus rendering the methodology as a highly eco-friendly, inexpensive alternative to the existing methods.
Unified Approach to Benzo[ d]thiazol-2-yl-Sulfonamides
Zále?ák, Franti?ek,Ková?, Ond?ej,Lachetová, Eli?ka,?t'astná, Nikola,Pospí?il, Ji?í
, p. 11291 - 11309 (2021/09/07)
In this paper, we report a unified approach to N-substituted and N,N-disubstituted benzothiazole (BT) sulfonamides. Our approach to BT-sulfonamides starts from simple commercially available building blocks (benzo[d]thiazole-2-thiol and primary and secondary amines) that are connected via (a) a S oxidation/S-N coupling approach, (b) a S-N coupling/S-oxidation sequence, or via (c) a S-oxidation/S-F bond formation/SuFEx approach. The labile N-H bond in N-monoalkylated BT-sulfonamides (pKa (BTSO2N(H)Bn) = 3.34 ± 0.05) further allowed us to develop a simple weak base-promoted N-alkylation method and a stereoselective microwave-promoted Fukuyama-Mitsunobu reaction. N-Alkyl-N-aryl BT-sulfonamides were accessed with the help of the Chan-Lam coupling reaction. Developed methods were further used in stereo and chemoselective transformations of podophyllotoxin and several amino alcohols.
BENZOTHIAZOLE COMPOUNDS AND USES THEREOF
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Page/Page column 69, (2021/12/29)
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.