21879-09-4

Basic information

• Product Name: N-[1-(methylsulfanyl)-9H-fluoren-2-yl]acetamide
• CAS NO: 21879-09-4
• Molecular Formula: C₁₆H₁₅NOS
• Molecular Weight: 269.3614
• Mol File: 21879-09-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 480°C at 760 mmHg
• Flash Point: 244.1°C
• Density: 1.25g/cm³
• Vapor Pressure: 2.25E-09mmHg at 25°C
• Refractive Index: 1.667
• CAS DataBase Reference: N-[1-(methylsulfanyl)-9H-fluoren-2-yl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-(methylsulfanyl)-9H-fluoren-2-yl]acetamide(21879-09-4)
• EPA Substance Registry System: N-[1-(methylsulfanyl)-9H-fluoren-2-yl]acetamide(21879-09-4)

Safety Data

• Hazardous Substances Data: 21879-09-4(Hazardous Substances Data)

Upstream product

• 1115-47-5 N-acetyl-DL-methionine 
• 6098-44-8 NA-AAF 
• 53-95-2 N-Hydroxy-2-acetylaminofluoren 

Relevant articles and documents

Substituent effects on the bioactivation of 2-(N-hydroxyacetamido)fluorenes by N-arylhydroxamic acid N,O-cyltransferase

A series of 7-substituted analogues of 2-(N-hydroxyacetamido)fluorene (1) was subjected to bioactivation by a partially purified preparation of hamster hepatic AHAT, and the rates of methylthio adduct formation resulting from the reaction of the activated intermediates with N-acetylmethionine were determined. Electronegative substituents enhanced the amount of adduct formed; this finding contrasted with the results of a previous study in which it was found that electron-donating substituents facilitated the mechanism-based inactivation of AHAT by analogues of 1. The structures of the adducts formed from reaction of the activated forms of several of the 7-substituted compounds with N-acetylmethionine and with 2'-deoxyguanosine were determined; the types of adducts formed were similar to those formed with electrophiles generated by the AHAT-catalyzed activation of 1. Electronegative substituents enhanced the amount of adducts formed in the reaction with 2'-deoxyguanosine as well as with N-acetylmethionine.