219311-15-6

Basic information

• Product Name: 5-(4-methoxyphenyl)barbituric acid
• Synonyms: 5-(4-methoxyphenyl)barbituric acid
• CAS NO: 219311-15-6
• Molecular Weight: 234.211
• Mol File: 219311-15-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(4-methoxyphenyl)barbituric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methoxyphenyl)barbituric acid(219311-15-6)
• EPA Substance Registry System: 5-(4-methoxyphenyl)barbituric acid(219311-15-6)

Safety Data

• Hazardous Substances Data: 219311-15-6(Hazardous Substances Data)

Upstream product

• 31221-06-4 5-diazo-pyrimidine-2,4,6-trione 
• 100-66-3 methoxybenzene 
• 679788-76-2 4-methoxyphenyl ethyl malonate 
• 57-13-6 urea 
• 23197-67-3 diethyl 2-(4-methoxyphenyl)malonate 

Relevant articles and documents

Direct Synthesis of 5-Aryl Barbituric Acids by Rhodium(II)-Catalyzed Reactions of Arenes with Diazo Compounds

A commercially available rhodium(II) complex catalyzes the direct arylation of 5-diazobarbituric acids with arenes, allowing straightforward access to 5-aryl barbituric acids. Free N-H groups are tolerated on the barbituric acid, with no complications arising from N-H insertion processes. This method was applied to the concise synthesis of a potent matrix metalloproteinase (MMP) inhibitor.

Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds

PCT No. PCT/EP96/05766 Sec. 371 Date Aug. 26, 1998 Sec. 102(e) Date Aug. 26, 1998 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/23465 PCT Pub. Date Jul. 3, 1997Compounds of formula I, useful as matrix metalloprotease inhibitors, wherein X, Y and Z are each oxygen; R1 is selected from the group consisting of (a) n-octyl, (b) n-decyl, (c) biphenyl and (d) (4-phenoxy)phenyl, wherein the terminal monocycle for moieties (c)-(d) is unsubstituted or substituted by a substituent selected from the group consisting of -NH2, -NO2, -SO2NH2, -SO2CH3, acetyl, hydroxy, methoxy, ethoxy, cyano and halogen; R2 and R3 are each hydrogen; and R4 and R5, together with the nitrogen atom to which they are bound, form a piperazinyl or piperidyl ring, wherein the piperazinyl ring is substituted in the 4-position with a substituent selected from the group consisting of (a) a 6-membered aromatic monocycle having 0, 1 or 2 nitrogen atoms and the remainder of the atoms in the monocycle being carbon and (b) hydroxy-C1-C6 alkyl, wherein the monocycle is unsubstituted or substituted by a substituent selected from the group consisting of halogen, -NH2, -NO2, -SO2NH2, -SO2CH3, acetyl and cyano.