219518-19-1Relevant articles and documents
Key disaccharide repeat unit of glucuronic mannan oligosaccharide and preparation method of key disaccharide repeat unit
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Paragraph 0035-0039, (2021/01/28)
The invention provides a skeleton structure of a key disaccharide repeat unit of glucuronic mannan oligosaccharide and a preparation method of the skeleton structure. According to the key disacchariderepeat unit, glucose and mannose are used as raw materials, the key disaccharide repeat unit of glucuronic mannan oligosaccharide for treating or/and preventing Parkinson's disease and nephropathy isprepared through simple and easy-to-implement synthesis steps, and leaving groups of the key disaccharide repeat unit can be used as a glycosyl donor after being modified. The glucuronic acid can beused as a glycosyl receptor after four-position hydroxyl protecting groups of the glucuronic acid are removed, can be conveniently used for extending a carbohydrate chain of glucuronic mannan oligosaccharide, and has a key application value in the field of synthesis of the glucuronic mannan oligosaccharide.
Stereoselective Phenylselenoglycosylation of Glycals Bearing a Fused Carbonate Moiety toward the Synthesis of 2-Deoxy-β-galactosides and β-Mannosides
Li, Zhongjun,Meng, Shuai,Yao, Wang,Zhong, Wenhe
supporting information, (2020/04/09)
A phenylselenoglycosylation reaction of glycal derivatives mediated by diphenyl diselenide and phenyliodine(III) bis(trifluoroacetate) under mild conditions is described. Stereoselective glycosylation has been achieved by installing fused carbonate on those glycals. 3,4-O-Carbonate galactals and 2,3-O-carbonate 2-hydroxyglucals are converted into corresponding glycosides in good yields with excellent β-selectivity, resulting in 2-phenylseleno-2-deoxy-β-galactosides and 2-phenylseleno-β-mannosides which are good precursors of 2-deoxy-β-galactosides and β-mannosides, respectively.
Synthesis of trisaccharide repeating unit of fucosylated chondroitin sulfate
He, Haiqing,Chen, Dong,Li, Xiaomei,Li, Chengji,Zhao, Jin-Hua,Qin, Hong-Bo
supporting information, p. 2877 - 2882 (2019/03/21)
We described the chemical synthesis of a sulfated trisaccharide repeating unit of fucosylated chondroitin sulfate (FCS), which has significant anticoagulant activity. Well-functionalized monosaccharides were readily prepared, and highly efficient glycosyl