1152-39-2Relevant articles and documents
Simple and Practical Real-Time Analysis of Solid-Phase Reactions by Thin-Layer Chromatography
Wu, Chia-Hui,Chen, Chun C.,Lin, Su-Ching,Wang, Cheng-Chung
, p. 1430 - 1436 (2018)
Solid-phase synthesis is a practical approach for simplifying the time-consuming and routine purification steps in the preparation of numerous naturally occurring molecules; however, studying such reactions is difficult due to the lack of a convenient monitoring method. By using thin-layer chromatography in conjunction with a photolabile linker on a resin, we developed a convenient and simple method for monitoring solid-phase reactions in real time by thin-layer chromatography. This method provides a user-friendly protocol for examining reaction conditions for solid-state syntheses.
Total Synthesis of Nucleoside Antibiotics Plicacetin and Streptcytosine A
Fu, Jiqiang,Laval, Stephane,Yu, Biao
, p. 7076 - 7084 (2018)
Disaccharide nucleoside antibiotics plicacetin and streptcytosine A (also named rocheicoside A) were effectively synthesized through the common precursor cytosamine. The amosamine and amicetose moieties were efficiently assembled through an α-selective O-
Site-Selective Acylation of Pyranosides with Oligopeptide Catalysts
Seitz, Alexander,Wende, Raffael C.,Roesner, Emily,Niedek, Dominik,Topp, Christopher,Colgan, Avene C.,McGarrigle, Eoghan M.,Schreiner, Peter R.
, p. 3907 - 3922 (2021/03/09)
Herein, we report the oligopeptide-catalyzed site-selective acylation of partially protected monosaccharides. We identified catalysts that invert site-selectivity compared to N-methylimidazole, which was used to determine the intrinsic reactivity, for 4,6
Synthesis method of voglibose
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Paragraph 0060- 0061; 0068-0070, (2021/08/07)
The invention provides a synthesis method of voglibose, and solves the technical problems that in an existing synthesis method of voglibose, raw materials are difficult to obtain, high in price, large in investment, low in yield and not suitable for industrial production. The synthesis method comprises the steps: synthesizing a compound V by taking glucose monohydrate and sodium acetate as raw materials through eleven reaction steps; and preparing a compound VIII from the compound V through an addition reaction, a ring-opening reaction and an aldol condensation reaction, and thus obtaining voglibose through amination reduction of the compound VIII. The synthesis method of voglibose can be widely applied to the technical field of voglibose synthesis methods.