219552-64-4

Basic information

• Product Name: tert-butyl 6-nitro-1H-indole-1-carboxylate
• Synonyms: tert-butyl 6-nitro-1H-indole-1-carboxylate;tert-butyl 6-nitroindoline-1-carboxylate;1-BOC-6-nitroindole
• CAS NO: 219552-64-4
• Molecular Formula: C13H14N2O4
• Molecular Weight: 262.26126
• Mol File: 219552-64-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 395.3±34.0 °C(Predicted)
• Appearance: /
• Density: 1.26±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-butyl 6-nitro-1H-indole-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 6-nitro-1H-indole-1-carboxylate(219552-64-4)
• EPA Substance Registry System: tert-butyl 6-nitro-1H-indole-1-carboxylate(219552-64-4)

Safety Data

• Hazardous Substances Data: 219552-64-4(Hazardous Substances Data)

Usage

General Description

Tert-butyl 6-nitro-1H-indole-1-carboxylate is a chemical compound with the molecular formula C15H17NO4. It is a yellow, crystalline solid that is commonly used in organic synthesis and medicinal chemistry. tert-butyl 6-nitro-1H-indole-1-carboxylate belongs to the class of indole derivatives, which are known for their wide range of biological activities. Tert-butyl 6-nitro-1H-indole-1-carboxylate is often used as a building block for the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity and ability to introduce specific functional groups. Additionally, it has been studied for its potential application as an antitumor agent. Overall, tert-butyl 6-nitro-1H-indole-1-carboxylate is a key intermediate in the preparation of various biologically active compounds.

Upstream product

• 75400-67-8 indole-1-carboxylic acid tert-butyl ester 
• 4769-96-4 6-nitroindole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 129488-00-2 6-amino-2,3-dihydroindole-1-carboxylic acid tert-butyl ester 
• 219508-62-0 tert-butyl 6-amino-1H-indole-1-carboxylate 
• 503614-54-8 1-(3-cyano-4-fluorophenyl)-5-{[6-(2-oxo-hexahydro-1H-azepin-1-yl)-2,3-dihydro-1H-indol-1-yl]carbonyl}-1H-pyrazole-3-carboxamide 

Relevant articles and documents

LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS

The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

Substituted benzazoles and methods of their use as inhibitors of Raf kinase

New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

Synthesis and reactions of N-protected 3-nitroindoles

Treatment of N-protected indoles 3 with acetyl nitrate generated in situ at low temperatures affords the corresponding 3-nitroindoles 2 in good to excellent yields. Deprotection of 1-acetyl-3-nitroindole (2h) with DBU gives 3-nitroindole (1). Reaction of