2198-19-8 Usage
Description
1-(2-hydroxy-4-methoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one, commonly known as curcumin, is a naturally occurring polyphenolic compound derived from the rhizome of the Curcuma longa plant, or turmeric. It exhibits a range of biological activities, such as antioxidant, anti-inflammatory, and anticancer properties, and has been widely researched for its potential therapeutic effects on various conditions, including cancer, diabetes, cardiovascular disease, and neurodegenerative disorders. Curcumin is also utilized as a food coloring and flavoring agent, and it is valued in traditional medicine for its health benefits. Its chemical structure, featuring two aromatic rings with methoxy and hydroxy groups and a conjugated system of double bonds, is responsible for its pharmacological properties.
Uses
Used in Pharmaceutical Applications:
Curcumin is used as a therapeutic agent for its potential effects on a wide range of conditions, including cancer, diabetes, cardiovascular disease, and neurodegenerative disorders. Its antioxidant, anti-inflammatory, and anticancer properties make it a promising candidate for pharmaceutical development.
Used in Food Industry:
In the food industry, curcumin is utilized as a natural coloring and flavoring agent due to its vibrant color and unique taste derived from the turmeric plant.
Used in Traditional Medicine:
Curcumin has been employed in traditional medicine for its health benefits, where it is believed to provide a range of therapeutic effects based on its antioxidant, anti-inflammatory, and anticancer properties.
Used in Cosmetics Industry:
Given its antioxidant and anti-inflammatory properties, curcumin may also find applications in the cosmetics industry for products aimed at promoting skin health and reducing signs of aging or inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 2198-19-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,9 and 8 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2198-19:
(6*2)+(5*1)+(4*9)+(3*8)+(2*1)+(1*9)=88
88 % 10 = 8
So 2198-19-8 is a valid CAS Registry Number.
InChI:InChI=1/C17H16O4/c1-20-13-6-3-12(4-7-13)5-10-16(18)15-9-8-14(21-2)11-17(15)19/h3-11,19H,1-2H3/b10-5+
2198-19-8Relevant articles and documents
Crystal-packing modes determine the solid-state ESIPT fluorescence in highly dipolar 2′-hydroxychalcones
Bordy, Mathieu,Bretonnière, Yann,Hasserodt, Jens,Jeanneau, Erwann,Tordo, Alix
supporting information, p. 12727 - 12731 (2021/10/06)
This work describes the systematic study of the structure-luminescence relationship of 15 hydroxy-chalcones directly in the crystal state. Chalcones are easily assembled at the gram scale allowing for efficient variation of their substitution motifs. Our molecule variants combine two modes of fluorescence generation, ESIPT and ICT, both known for their potential to achieve significant quantum yields even with emission in the red to near infrared, a region preferred for technologies as diverse as optoelectronics and chemical sensing. Quantum yields as high as 48% (at 665 nm) and emission wavelengths in the deep red region (710 nm, 5%) were achieved with variants equipped with a strained amino substituent in the donor portion (azetidinyl). Systematic XRD analysis of large monocrystals allowed for the identification of the subtle interplay of several inter- and intra-molecular parameters in achieving such performances, be it intramolecular planarity, non-classical H-bonds, and stacking modes.
Crystal structures, Hirshfeld surface analysis and PIXEL calculations of four (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one derivatives, containing methoxy substituents. The importance of π interactions
Gomes, Ligia R.,Low, John N.,Pinheiro, Alessandra C.,Turner, Alan B.,Wardell, James L.
, (2020/07/08)
A detailed structural analysis has been carried out on four chalcone (E)-1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one derivatives, having a varying number of methoxy substituents, namely (E)-3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one, (1),
NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
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Page/Page column 25; 27, (2018/07/29)
Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).
