128961-25-1

Basic information

• Product Name: 1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one
• Synonyms: 1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one
• CAS NO: 128961-25-1
• Molecular Weight: 234.295
• Mol File: 128961-25-1.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one(128961-25-1)
• EPA Substance Registry System: 1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one(128961-25-1)

Safety Data

• Hazardous Substances Data: 128961-25-1(Hazardous Substances Data)

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 503-60-6 3,3-dimethyl-allyl chloride 
• 870-63-3 prenyl bromide 

Downstream Products

• 1092462-95-7 4'-methoxy-4-methoxymethoxy-2'-prenyloxychalcone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 52601-06-6 1-(2-hydroxy-4-methoxy-3-(3-methyl-butyl-2-ene-1-yl)phenyl)ethanone 
• 28448-83-1 2′-hydroxyl-4′-methoxyl-5′-isopentenylacetophenone 
• 50773-40-5 3',5'-diprenyl-2'-hydroxy-4'-methoxyacetophenone 
• 32541-39-2 8-acetyl-2,2-dimethyl-5-methoxychroman 
• 1622397-81-2 (E)-1-(2-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl)-3-p-tolyl prop-2-en-1-one 
• 1622397-82-3 (E)-3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl)prop-2-en-1-one 
• 1622397-83-4 (E)-3-(4-bromophenyl)-1-(2-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl)prop-2-en-1-one 
• 1622397-85-6 C₃₁H₃₈O₇ 
• 1622397-87-8 (E)-3-(3,4-dihydroxyphenyl)-1-(2-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl)prop-2-en-1-one 
• 1622397-89-0 (2Z)-6-methoxy-5-(3-methylbut-2-enyl)-2-(p-tolylmethylene)benzofuran-3-one 
• 1622397-91-4 (2Z)-2-[(3,4-dimethoxyphenyl)methylene]-6-methoxy-5-(3-methylbut-2-enyl)benzofuran-3-one 
• 1622397-93-6 (E)-3-(4'-fluoro-4-biphenylyl)-1-(2-hydroxy-4-methoxyphenyl)2-propen-1-one 

Relevant articles and documents

Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification

4-Hydroxyderricin is a heat labile bioactive chalcone isolated from the plant Angelica keiskei. It received attention due to its antibiotic potency against several strains of bacteria including pathogens such as Staphylococcus aureus. Despite these promising pharmacological properties, the exact mode of action or the biological targets are still unknown. Here we report the synthesis and the application of a 4-hydroxyderricin probe for activity-based protein profiling (ABPP) in S. aureus. Due to the heat sensitivity of the natural product we utilize a chemical tool for the mild and selective enrichment of labile probe-protein conjugates and report seryl-tRNA synthetase (STS) to be covalently modified by our probe. This modification results in inhibition of the amino acylation of tRNAs catalyzed by S. aureus STS which is an essential enzymatic pathway for bacterial viability.

Synthesis and antibacterial activity of four natural chalcones and their derivatives

Four natural chalcones bearing hydroxyisoprenyl or prenyl groups, named Paratocarpin E (2), Xanthoangelol D (3), Angusticornin A (4) and Kanzonol C (5), were prepared by employing the Claisen-Schmidt condensation as the key step. In an attempt to investigate the effect of the hydroxyisoprenyl group on biological activity, two of their derivatives were also prepared for antibacterial activity research. The synthesized compounds were investigated for their expected antibacterial activities against Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus) as well as Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa). Paratocarpin E (2) was found to be the most potent against two Gram positive bacteria while the majority of the remaining compounds showed promising activity as well. However, all of the compounds were inactive against both Gram-negative bacteria.

Bavachinin analogues as agonists of pan-peroxisome proliferator-activated receptors

Peroxisome proliferator-activated receptors (PPARs) agonists contribute to the regulation of glucose, lipid, and cholesterol metabolism and have emerged as key targets to treat metabolic syndrome. In our previous study, the natural compound bavachinin was found to have pan-PPAR agonist activity. In this study, five isoflavones, three isoflavanones, and five scaffold-hopping analogues of bavachinin were designed, synthesised, and evaluated through reporter gene assays for pan-PPAR agonist activity. The analogue 2-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-2,3-dihydroquinolin-4(1H)-one (21) was identified as a pan-PPAR agonist, exhibiting substantially higher PPAR α/β agonist activity and equal PPAR-γ agonist activity than does bavachinin.