28448-83-1Relevant articles and documents
2-phenylchroman-4-one derivatives and antiviral composition comprising the same
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, (2020/09/10)
The present invention relates to a 2-phenylchroman-4-one derivative or a pharmaceutically acceptable salt thereof, a method for manufacturing the same, and a therapeutic agent for MERS containing the same as an active component. A compound containing the
Bavachinin analogues as agonists of pan-peroxisome proliferator-activated receptors
Yi, Jingyu,Du, Guoxin,Zhao, Yuanyuan,Zhang, Liuqiang,Li, Bo,Zhu, Weiliang,Huang, Cheng,Li, Yiming,Guo, Fujiang
, p. 1851 - 1862 (2018/06/18)
Peroxisome proliferator-activated receptors (PPARs) agonists contribute to the regulation of glucose, lipid, and cholesterol metabolism and have emerged as key targets to treat metabolic syndrome. In our previous study, the natural compound bavachinin was found to have pan-PPAR agonist activity. In this study, five isoflavones, three isoflavanones, and five scaffold-hopping analogues of bavachinin were designed, synthesised, and evaluated through reporter gene assays for pan-PPAR agonist activity. The analogue 2-(4-hydroxyphenyl)-6-isopentenyl-7-methoxy-2,3-dihydroquinolin-4(1H)-one (21) was identified as a pan-PPAR agonist, exhibiting substantially higher PPAR α/β agonist activity and equal PPAR-γ agonist activity than does bavachinin.
Method for synthesizing active ingredient intermediate of traditional Chinese medicine fructus psoraleae
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, (2018/11/22)
The invention relates to a method for synthesizing an active ingredient intermediate of a traditional Chinese medicine fructus psoraleae. The method comprises the following steps: (a) mixing paeonol,1-bromo-3-methyl-2-butene and acetone, and adding potass