52601-06-6

Basic information

• Product Name: Ethanone, 1-[2-hydroxy-4-methoxy-3-(3-methyl-2-butenyl)phenyl]-
• CAS NO: 52601-06-6
• Molecular Formula: C14H18O3
• Molecular Weight: 234.295
• Mol File: 52601-06-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2-hydroxy-4-methoxy-3-(3-methyl-2-butenyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2-hydroxy-4-methoxy-3-(3-methyl-2-butenyl)phenyl]-(52601-06-6)
• EPA Substance Registry System: Ethanone, 1-[2-hydroxy-4-methoxy-3-(3-methyl-2-butenyl)phenyl]-(52601-06-6)

Safety Data

• Hazardous Substances Data: 52601-06-6(Hazardous Substances Data)

Upstream product

• 128961-25-1 1-(4-methoxy-2-((3-methylbut-2-en-1-yl)oxy)phenyl)ethan-1-one 
• 54730-26-6 4-methoxymethoxy-3-(3,3-dimethylallyl)-2-hydroxyacetophenone 
• 1314539-20-2 2'-prenyloxy-4'-methoxymethoxyacetophenone 
• 65490-08-6 2-hydroxy-4-(methoxymethoxy)acetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 870-63-3 prenyl bromide 
• 1393921-61-3 1-(4-methoxy-2-((2-methylbut-3-yn-2-yl)oxy)phenyl)ethanone 
• 19825-40-2 2,4-Dihydroxy-3-C-prenylacetophenone 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 56075-16-2 2,4-Dimethoxy-3-C-prenylacetophenone 

Downstream Products

• 1092462-94-6 2'-hydroxyl-4'-methoxy-4-methoxymethoxy-3'-prenyl-chalcone 
• 877875-97-3 C₂₁H₂₄O₄ 
• 1092462-98-0 C₂₃H₂₈O₅ 
• 54647-08-4 4-hydroxyderricin 

Relevant articles and documents

Novel 3′,5′-diprenylated chalcones inhibited the proliferation of cancer cells in?vitro by inducing cell apoptosis and arresting cell cycle phase

A double Claisen rearrangements synthetic strategy was established for the total synthesis of 4,4′-dimethyl medicagenin (compound 6c). A series of its analogs also were prepared, including two novel 3′,5′-diprenylated chalcones, in which ring B was replaced by azaheterocycle. The structures of the twenty-two newly synthesized compounds were confirmed by 1H NMR, 13C NMR and ESI-MS. In?vitro, the cytotoxicity of the target compounds was evaluated using cancer cells. Noticeably, compound 10 exhibited broad-spectrum cytotoxicity on PC3 prostate cancer cells, MDA-MB-231 breast cancer cells (MDA), HEL and K562 erythroleukemia cells with IC50 values of 2.92, 3.14, 1.85 and 2.64?μM, respectively. Further studies indicated that compound 10 induced apoptosis and arrested the cell cycle phase of the above mentioned four cancer cell lines. By contrast, compound 6g selectively displayed potent inhibitory activity against the proliferation of HEL cells with an IC50 value of 4.35?μM. Compound 6g slightly induced apoptosis and arrested cell cycle phase of HEL cells. Preliminary structure-activity relationship studies indicated that, in all cancer cell lines evaluated, the 3-pyridinyl group was essential for cytotoxicity.

Synthesizing method of isoamylene-based chalcone derivative and application of isoamylene-based chalcone derivative in pharmaceutical industry

The invention discloses a synthesizing method of an isoamylene-based chalcone derivative and application of the isoamylene-based chalcone derivative in pharmaceutical industry. The derivative involvedin the method is synthesized in the steps that 1, a com

Synthesis of 4-hydroxyderricin and related derivatives

Naturally occurring chalcones, namely 4-hydroxyderricin (1), xanthoangelol H (2), deoxyxanthoangelol H (3), and deoxydihydroxanthoangelol H (4), were first synthesized and evaluated for antibacterial activities.