219814-29-6Relevant articles and documents
Efficient Synthesis of tert-Butyl 2,4-Dialkynylated and 2-Alkynylated-4-Arylated-1H-Imidazole-1-Carboxylate via Regioselective Sonogashira Cross-Coupling Reaction
Jismy, Badr,El Qami, Abdelkarim,Jacquemin, Johan,Guillot, Regis,Tikad, Abdellatif,Abarbri, Mohamed
, p. 4495 - 4507 (2021/08/30)
An efficient regioselective cross-coupling reactions of tert-butyl 2,4-dibrominated-5-methyl-1H-imidazole-1-carboxylate is reported. This new synthetic route runs under simple and mild conditions and selectively gives an easy access to 2,4-dialkynylated a
Access to imidazo[1,2-a]imidazolin-2-ones and functionalization through Suzuki-Miyaura cross-coupling reactions
Grosse, Sandrine,Pillard, Christelle,Himbert, Franck,Massip, Stephane,Leger, Jean Michel,Jarry, Christian,Bernard, Philippe,Guillaumet, Gerald
, p. 4146 - 4155 (2013/07/11)
We report herein a synthetic pathway to new 6(5)-bromo-5(6)- methylimidazo[1,2-a]imidazolin-2-ones. The synthetic potential of these scaffolds was demonstrated by displacing bromine by Suzuki-Miyaura cross-coupling reactions. A large panel of boronic acids (aryl, heteroaryl or vinyl) could easily be introduced, giving access to a large and diversified library of 6(5)-substituted 5(6)-methylimidazo[1,2-a]imidazolin-2-ones. A new route to 6(5)-bromo-5(6)-methylimidazo[1,2-a]imidazolin-2-ones have been developed. A novel and effective strategy of functionnalization of these scaffolds throught Suzuki-Miyaura cross coupling reactions is reported. Thanks to this methodology, a large panel of boronic acids were easily introduced, giving access to a diversified library of 6(5)-substituted 5(6)-methylimidazo[1, 2-a]imidazolin-2-ones. Copyright