220641-87-2

Basic information

• Product Name: METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL
• Synonyms: METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE;METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL;METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HYDROCHLORIDE;CHEMBRDG-BB 4003545;N-METHYL-N-TETRAHYDRO-2H-PYRAN-4-YLAMINE;N-METHYL-TETRAHYDRO-2H-PYRAN-4-AMINE;N-METHYL-TETRAHYDRO-2H-PYRAN-4-AMINE HYDROCHLORIDE;4-(Methylamino)tetrahydro-2H-pyran
• CAS NO: 220641-87-2
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17352
• Mol File: 220641-87-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 165 °C at 760 mmHg
• Flash Point: 56.1 °C
• Appearance: /
• Density: 0.93 g/cm³
• Vapor Pressure: 1.91mmHg at 25°C
• Refractive Index: 1.448
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.01±0.20(Predicted)
• CAS DataBase Reference: METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL(220641-87-2)
• EPA Substance Registry System: METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL(220641-87-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 220641-87-2(Hazardous Substances Data)

Usage

General Description

Methyl-(tetrahydro-pyran-4-yl)-amine HCl is a chemical compound that consists of a methyl group and an amine group attached to a tetrahydro-pyran-4-yl ring, with a hydrochloride salt form. It is commonly used in organic synthesis as a building block for various pharmaceuticals and agrochemicals. METHYL-(TETRAHYDRO-PYRAN-4-YL)-AMINE HCL is also used as a reagent in the production of fine chemicals and pharmaceutical intermediates. It is important to handle this substance with care, as it can be hazardous if not used properly.

InChI:InChI=1/C6H13NO/c1-7-6-2-4-8-5-3-6/h6-7H,2-5H2,1H3

Upstream product

• 874888-66-1 4-[N-(tetrahydropyran-4-yl)aminomethyl]-nitrobenzene 
• 229007-08-3 N-[(4-nitrophenyl)methyl]tetrahydro-N-methyl-2H-pyran-4-amine 

Downstream Products

• 220641-84-9 N-methyl-N-(tetrahydropyran-4-yl)carbamoyl chloride 
• 1304062-30-3 C₂₄H₃₀F₃N₃O₄ 
• 1373488-32-4 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-6-(methyl-tetrahydro-pyran-4-yl-amino)-pyridine-3-carboxylic acid amide 
• 1391978-10-1 2,4-difluoro-N-(2-methyl-5-{4-methyl-6-[methyl-(tetrahydropyran-4-yl)-amino]-pyrimidin-5-ylethynyl}-pyridin-3-yl)-benzenesulfonamide 
• 1184435-31-1 4-bromo-N-methyl-N-(tetrahydro-2H-pyran-4-yl)benzenesulfonamide 
• 1425972-87-7 1-(4-bromophenyl)-N-methyl-N-(tetrahydro-2H-pyran-4-yl)methanesulfonamide 
• 1578244-41-3 N₂-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N₈-methyl-N₈-(tetrahydro-2H-pyran-4-yl)pyrido[3,4-d]pyrimidine-2,8-diamine 
• 1356960-87-6 N-methyl-4-(3-nitrophenyl)-N-(tetrahydro-2H-pyran-4-yl)-1H-imidazole-1-carboxamide 

Relevant articles and documents

Hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes to (N,N-disubstituted aminomethyl)anilines catalyzed by palladium-nickel bimetallic nanoparticles

Since palladium-catalysts have strong abilities for both hydrogenation of nitro-group and hydrogenolysis of benzylamine, they have a much lower chemoselectivity for the hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes. In this article, component stable Pd-Ni bimetallic nanoparticles were prepared by simply heating RANEY-Ni and Na2PdCl4 together in water. They demonstrated novel synergistic effects when they were used as a bimetallic catalyst, by which a highly efficient and chemoselective hydrogenation of (N,N-disubstituted aminomethyl)nitrobenzenes to (N,N-disubstituted aminomethyl)anilines was achieved.