229007-08-3

Basic information

• Product Name: 2H-Pyran-4-amine, tetrahydro-N-methyl-N-[(4-nitrophenyl)methyl]-
• CAS NO: 229007-08-3
• Molecular Formula: C13H18N2O3
• Molecular Weight: 250.298
• Mol File: 229007-08-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2H-Pyran-4-amine, tetrahydro-N-methyl-N-[(4-nitrophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran-4-amine, tetrahydro-N-methyl-N-[(4-nitrophenyl)methyl]-(229007-08-3)
• EPA Substance Registry System: 2H-Pyran-4-amine, tetrahydro-N-methyl-N-[(4-nitrophenyl)methyl]-(229007-08-3)

Safety Data

• Hazardous Substances Data: 229007-08-3(Hazardous Substances Data)

Upstream product

• 7409-30-5 p-nitrobenzylamine 
• 392277-22-4 N-methyl-N-(tetrahydropyran-4-yl)amine hydrochloride 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 50-00-0 formaldehyd 
• 18600-42-5 4-nitrobenzylamine hydrochloride 
• 874888-66-1 4-[N-(tetrahydropyran-4-yl)aminomethyl]-nitrobenzene 

Downstream Products

• 220641-87-2 N-methyl-N-(tetrahydropyran-4-yl)amine 
• 106-49-0 p-toluidine 
• 229005-57-6 2-(4-piperidinophenyl)-N-(4-((N-tetrahydropyran-4-yl-N-methylamino)methyl)phenyl)-6,7-dihydro-5H-benzocyclohepten-8-carboxamide 
• 229005-16-7 N-[4-[N-methyl-N-(tetrahydropyran-4-yl)aminomethyl]phenyl]-7-(4-trifluoromethylphenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 229005-18-9 7-(4-ethoxyphenyl)-N-[4-[N-methyl-N-(tetrahydropyran-4-yl)-aminomethyl]phenyl]-2,3-dihydro-1-benzoxepin-4-carboxamide 
• 229005-52-1 2-(4-methylphenyl)-N-(4-{[methyl(tetrahydro-2H-pyran-4-yl)amino]methyl}phenyl)-6,7-dihydro-5H-benzo[a][7]annulene-8-carboxamide 
• 392277-22-4 N-methyl-N-(tetrahydropyran-4-yl)amine hydrochloride 
• 540-23-8 p-toluidine hydrochloride 
• 229007-09-4 4-[N-methyl-N-(tetrahydro-2H-pyran-4-yl)aminomethyl]aniline 

Relevant articles and documents

SYNTHESIS OF QUATERNARY SALT COMPOUNDS

The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.

Quaternary salt CCR2 antagonists

Quaternary salt compounds of Formula (I) or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.

Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: Synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety

The search for new small-molecule CCR5 antagonists by high-throughput screening (HTS) of the Takeda chemical library using [125I]RANTES and CHO/CCR5 cells led to the discovery of lead compounds (A, B) with a quaternary ammonium or phosphonium m