22072-19-1

Basic information

• Product Name: TETRAHYDROTHIOPYRAN-3-OL, 95
• Synonyms: TETRAHYDROTHIOPYRAN-3-OL, 95;Tetrahydro-2H-thiopyran-3-ol;thian-3-ol
• CAS NO: 22072-19-1
• Molecular Formula: C₅H₁₀OS
• Molecular Weight: 118.1973
• EINECS: 244-766-6
• Mol File: 22072-19-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 152.48°C (estimate)
• Flash Point: 107.2°C
• Appearance: /
• Density: 1.1400
• Vapor Pressure: 0.026mmHg at 25°C
• Refractive Index: 1.5351 (estimate)
• CAS DataBase Reference: TETRAHYDROTHIOPYRAN-3-OL, 95(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAHYDROTHIOPYRAN-3-OL, 95(22072-19-1)
• EPA Substance Registry System: TETRAHYDROTHIOPYRAN-3-OL, 95(22072-19-1)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 22072-19-1(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLORLESS VISCOUS LIQUID

InChI:InChI=1/C5H10OS/c6-5-2-1-3-7-4-5/h5-6H,1-4H2

Upstream product

• 19090-03-0 dihydro-2H-thiopyran-3(4H)-one 
• 555-31-7 aluminum isopropoxide 

Downstream Products

• 78839-08-4 Tetrahydrothiopyran-3-yl-Hydrogenphthalat 
• 19090-03-0 dihydro-2H-thiopyran-3(4H)-one 
• 94158-05-1 3-hydroxytetrahydro-2H-thiopyran-1,1-dioxide 
• 36165-01-2 thiacycloheptan-3-one 1,1-dioxide 
• 29431-37-6 tetrahydrothiopyran-3-one-1,1-dioxide 
• 112769-53-6 Methyl 3,4,5,8-tetrahydro-6-methyl-8-(3-nitrophenyl)-1,1-dioxo-2H-thiopyrano<3,2-b>pyridine-7-carboxylate 
• 130570-24-0 Methyl 2,3,4,5,6,9-hexahydro-7-methyl-9-(2-nitrophenyl)-1,1-dioxothiacyclohepteno<3,2-b>pyridine-8-carboxylate 
• 130570-23-9 Methyl 2,3,4,5,9,9a-Hexahydro-7-methyl-9-(2-nitrophenyl)-1,1-dioxothiacyclohepteno<3,2-b>pyridine-8-carboxylate 
• 112769-44-5 Ethyl 2,3,4,5,6,9-hexahydro-7-methyl-9-(3-nitrophenyl)-1,1-dioxo-thiacyclohepteno<3,2-b>pyridine-7-carboxylate 
• 112769-45-6 Ethyl 3,4,5,7,10,10a-hexahydro-8-methyl-10-(3-nitrophenyl)-1,1-dioxo-2H-thiacycloocteno<3,2-b>pyridine-9-carboxylate 
• 112769-86-5 Ethyl 3,4,5,6,10-hexahydro-8-methyl-10-(3-nitrophenyl)-1,1-dioxo-2H-thiacycloocteno<3,2-b>pyridine-9-carboxylate 
• 1439809-93-4 C₁₈H₂₀N₄O₂S₂ 

Relevant articles and documents

Conformational Analysis. 46. Conformational Equilibria in 3-Hydroxy-, 3-Methoxy-, and 3-Acetoxythianes, Their Sulfoxides and Sulfones, and Some Corresponding 3-Methyl Homologues

Conformational equilibria have been measured, by low-temperature carbon-13 and proton NMR spectroscopy, for 3-hydroxythiane, its two epimeric sulfoxides, and the corresponding sulfone and their methyl ethers and acetates, as well as the corresponding derivatives of 3-methyl-3-hydroxythiane and their acetates.Of particular note are large solvent and concentration effects on the conformational free energies, ΔG0ae, especially in cases where intramolecular and intermolecular hydrogen bonding are competitive.Thus, in 3-hydroxythiane, ΔG0 rises from -1.20 kcal/mol in 4 M CD2Cl2 to -0.22 kcal/mol in 0.0011 M CD2Cl2; for the corresponding cis sulfoxide the rise is from +1.3 kcal/mol in 0.0023 M CD2Cl2 and in the sulfone it is from -1.3 kcal/mol in 0.3 M CD3COCD3 to -0.9 kcal/mol in 0.3 M CD2Cl2 to -0.16 kcal/mol in 0.002 M CD2Cl2.

PHARMACEUTICALLY USEFUL SUBSTITUTED THIACYCLOALKENO [3,2-B]PYRIDINES, COMPOSITIONS AND METHOD OF USE

Novel substituted thiacycloalkeno [3,2-b]pyridines are described. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstrictor activity.