220805-31-2

Basic information

• Product Name: 2R-benzyloxymethylpentanoic acid
• Synonyms: 2R-benzyloxymethylpentanoic acid
• CAS NO: 220805-31-2
• Molecular Weight: 222.284
• Mol File: 220805-31-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2R-benzyloxymethylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2R-benzyloxymethylpentanoic acid(220805-31-2)
• EPA Substance Registry System: 2R-benzyloxymethylpentanoic acid(220805-31-2)

Safety Data

• Hazardous Substances Data: 220805-31-2(Hazardous Substances Data)

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 2163-48-6 diethyl propylmalonate 
• 100-51-6 benzyl alcohol 
• 143868-89-7 3-(1-oxopentyl)-4(S)-(phenylmethyl)-2-oxazolidinone 
• 638-29-9 n-valeryl chloride 
• 220805-27-6 3-(3-benzyloxymethyl-2R-n-propylpropionyl)-4S-benzyloxazolidin-2-one 

Downstream Products

• 63095-51-2 (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one 
• 220805-49-2 3-(5S-isopropyl-4S-methoxycarbonyl-2-phenyl-4,5-dihydrooxazol-4-yl)-3S-hydroxy-2R-n-propyl-N,N-diethylpropionamide 
• 211866-70-5 [1R-[1S,4R,5S]]-1-(1-hydroxy-2-methylpropyl)-4-n-propyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione 
• 220805-35-6 2R-benzyloxymethylpentanoic acid diethylamide 

Relevant articles and documents

Preparation method for brivaracetam intermediate

The invention discloses a preparation method for (R)-4-propyl-4,5-dihydrofuran-2-one. The preparation method comprises the following steps: subjecting a carboxylic acid compound to chiral resolution so as to obtain an R-configuration carboxylic acid compound and an S-configuration carboxylic acid compound; and separately subjecting the R-configuration carboxylic acid compound and/or the S-configuration carboxylic acid compound to a reaction so as to obtain (R)-4-propyl-4,5-dihydrofuran-2-one. According to the preparation method, a synthetic route is ingeniously designed, and the two opticallypure isomers obtained through chiral resolution of the carboxylic acid compound are separately utilized by different reaction routes, so the target compound is eventually prepared; and the method improves the utilization rate of the isomers while ensuring optical purity and eliminates the cumbersome steps of racemization and re-splitting of the other half of the isomers.