143868-89-7

Basic information

• Product Name: 2-Oxazolidinone, 3-(1-oxopentyl)-4-(phenylmethyl)-, (S)-
• CAS NO: 143868-89-7
• Molecular Formula: C15H19NO3
• Molecular Weight: 261.321
• Mol File: 143868-89-7.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 3-(1-oxopentyl)-4-(phenylmethyl)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 3-(1-oxopentyl)-4-(phenylmethyl)-, (S)-(143868-89-7)
• EPA Substance Registry System: 2-Oxazolidinone, 3-(1-oxopentyl)-4-(phenylmethyl)-, (S)-(143868-89-7)

Safety Data

• Hazardous Substances Data: 143868-89-7(Hazardous Substances Data)

Upstream product

• 90719-32-7 (S)-4-Benzyl-2-oxazolidinone 
• 638-29-9 n-valeryl chloride 
• 2510-33-0 N-benzyl-2-oxazolidinone 
• 2082-59-9 pentanoic anhydride 
• 109-52-4 valeric acid 
• 101711-90-4 (S)-4-benzyl-2-oxazolidinone lithium salt 

Downstream Products

• 156546-61-1 (S)-4-Benzyl-3-((S)-2-phenylsulfanyl-pentanoyl)-oxazolidin-2-one 
• 225377-55-9 3-<(R)-<2-(1,1-dimethylethoxy)-2-oxoethyl>-1-oxopentyl>-4(S)-(phenylmethyl)-2-oxazolidinone 
• 220856-29-1 (4S)-4-benzyl-3-[(2R)-2-propylpent-4-enoyl]-1,3-oxazolidin-2-one 
• 220805-27-6 3-(3-benzyloxymethyl-2R-n-propylpropionyl)-4S-benzyloxazolidin-2-one 
• 423159-10-8 (4S)-4-benzyl-3-[(2S)-2-methylpentanoyl]-1,3-oxazolidin-2-one 
• 912654-40-1 (S)-4-Benzyl-3-[(E)-(2S,3R,5R)-5-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-6-(4-methoxy-benzyloxymethyl)-2-propyl-non-6-enoyl]-oxazolidin-2-one 
• 220805-31-2 2R-benzyloxymethylpentanoic acid 
• 220805-35-6 2R-benzyloxymethylpentanoic acid diethylamide 
• 211866-70-5 [1R-[1S,4R,5S]]-1-(1-hydroxy-2-methylpropyl)-4-n-propyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione 
• 225378-26-7 (R)-3-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-hexanoic acid 
• 225377-74-2 N-<1(S)-(cyclohexylmethyl)-2(R),3(S)-dihydroxy-5-methylhexyl>-2(R)-<2-(1,1-dimethylethoxy)-2-oxoethyl>pentanamide 
• 143879-15-6 (α-phenylthio)valeraldehyde 
• 247182-93-0 (4S,2'R)-3-(2'-isopropyl-1'-oxopentyl)-4-benzyl-2-oxazolidinone 
• 1000053-27-9 (S)-4-benzyl-3-[(2R,4E)-6-benzyloxy-2-propylhex-4-enoyl]oxazolidin-2-one 

Relevant articles and documents

Preparation method of (R)-4-propyl-dihydrofuran-2-one and preparation intermediate of (R)-4-propyl-dihydrofuran-2-one

The invention discloses a preparation method of (R)-4-propyl-dihydrofuran-2-one and a preparation intermediate of (R)-4-propyl-dihydrofuran-2-one. The preparation method of the intermediate comprisesthe following steps: (1) in the presence of an acid or an alkali, carrying out hydrolysis reaction on a compound I to obtain a compound II or a salt thereof; and (2) carrying out reduction reaction onthe compound II or the salt thereof and a reducing agent to obtain a compound III. According to the preparation route disclosed by the invention, the use of flammable and explosive reaction reagentsin the existing route is avoided; reagents which are low in cost and easy to obtain in industry are used; compared with the prior art, the method has the advantages of low cost, safety in production,realization of the purification and the separation of the intermediate by using the acid-base property of the compound and adopting the mode of adjusting the pH value of the system in the reaction process and the post-treatment operation, avoiding of recrystallization, filtration and other tedious operation modes, simplification of the operation, and suitableness for industrial large-scale production.

PROCESS FOR PREPARING OPTICALLY PURE (R)-4-N-PROPYL-DIHYDROFURAN-2(3H)-ONE

The present invention discloses a process for preparing optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one, belonging to the field of chemical synthesis. According to the process, optically pure (S)-3-n-pentanoyl-4-substituted oxazol-2-one is used as a starting material, and after alkylation, reduction, cyano hydrolysis, lactonization, the product optically pure (R)-4-n-propyl-dihydrofuran-2(3H)-one is given. The preparation process has the advantages of easy availability of raw materials, low price, high yield, high optical purity of product, simple reaction conditions and simple operations.

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