22091-39-0

Basic information

• Product Name: 4-CHLOROMETHYL-2-(4-FLUOROPHENYL) OXAZOLE
• Synonyms: 4-CHLOROMETHYL-2-(4-FLUOROPHENYL) OXAZOLE;4-FCPO
• CAS NO: 22091-39-0
• Molecular Formula: C₁₀H₇ClFNO
• Molecular Weight: 211.62
• Mol File: 22091-39-0.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 316.64°C at 760 mmHg
• Flash Point: 145.299°C
• Appearance: /
• Density: 1.301g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 4-CHLOROMETHYL-2-(4-FLUOROPHENYL) OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROMETHYL-2-(4-FLUOROPHENYL) OXAZOLE(22091-39-0)
• EPA Substance Registry System: 4-CHLOROMETHYL-2-(4-FLUOROPHENYL) OXAZOLE(22091-39-0)

Safety Data

• Hazardous Substances Data: 22091-39-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H7ClFNO/c11-5-9-6-14-10(13-9)7-1-3-8(12)4-2-7/h1-4,6H,5H2

Upstream product

• 824-75-9 p-fluorobenzamide 
• 534-07-6 1,3-Dichloroacetone 
• 885273-80-3 (2-(4-fluorophenyl)oxazol-4-yl)methanol 
• 403-43-0 4-fluorobenzoyl chloride 
• 456-22-4 4-Fluorobenzoic acid 
• 1065102-64-8 methyl 2-(4-fluorophenyl)-1,3-oxazole-4-carboxylate 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 501361-99-5 2-(4-fluorophenyl)-4-(iodomethyl)oxazole 
• 877880-12-1 C₂₁H₂₆FNO₄ 
• 22087-28-1 2-(2-(4-fluorophenyl)oxazol-4-yl)acetonitrile 
• 1314887-15-4 4-(dimethylamino)-2-(2-(4-fluorophenyl)oxazol-4-yl)butanenitrile 
• 1314887-16-5 3-(2-(4-fluorophenyl)oxazol-4-yl)-N₁,N₁-dimethylbutane-1,4-diamine 
• 1016734-82-9 2-(2-(4-fluorophenyl)oxazol-4-yl)ethanamine 
• 1589081-04-8 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-(4-fluorophenyl)oxazol-4-yl)methylthio)pyrimidine-5-carbonitrile 

Relevant articles and documents

Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents

The benzothiazinone (BTZ) scaffold compound PBTZ169 kills Mycobacterium tuberculosis by inhibiting the essential flavoenzyme DprE1, consequently blocking the synthesis of the cell wall component arabinans. While extraordinarily potent against M. tuberculosis with a minimum inhibitory concentration (MIC) less than 0.2 ng/mL, its low aqueous solubility and bioavailability issues need to be addressed. Here, we designed and synthesized a series of 6-methanesulfonyl substituted BTZ analogues; further exploration introduced five-member aromatic heterocycles as linkers to attach an aryl group as the side chain. Our work led to the discovery of a number of BTZ derived compounds with potent antitubercular activity. The optimized compounds 6 and 38 exhibited MIC 47 and 30 nM, respectively. Compared to PBTZ169, both compounds displayed increased aqueous solubility and higher stability in human liver microsomes. This study suggested that an alternative side-chain modification strategy could be implemented to improve the druglike properties of the BTZ-based compounds.

COMPOUNDS AND METHODS for the inhibition of HDAC

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.

6,7-DIOXYALKYLTETRAHYDROISOQUINOLINE COMPOUNDS

The present invention relates to a 6,7-dioxyalkyltetrahydroisoquinoline compound, or a salt or solvate thereof according to formula I: (formula I), (I) wherein R represents hydrogen or a fluorinated alkyl group, and R2 and R3 independently represents hydrogen or an alkyl group.