220936-57-2

Basic information

• Product Name: (R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: (R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 220936-57-2
• Molecular Weight: 363.48
• Mol File: 220936-57-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline(220936-57-2)
• EPA Substance Registry System: (R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline(220936-57-2)

Safety Data

• Hazardous Substances Data: 220936-57-2(Hazardous Substances Data)

Upstream product

• 52250-50-7 1-phenyl-3,4-dihydroisoquinoline 
• 98-59-9 p-toluenesulfonyl chloride 
• 51608-60-7 phenyl N-tosyl imine 
• 172794-67-1 (4R,5R)-2-(2-Bromo-benzyl)-4,5-bis-(1-methoxy-1-methyl-ethyl)-[1,3]dioxolane 
• 220936-55-0 (R)-(+)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2-dihydroisoquinoline 
• 213595-50-7 (-)-N-<(αR)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide 
• 1613-90-7 4-methoxy-N-[(E)-phenylmethylidene]aniline 

Downstream Products

• 180272-45-1 (R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Enantioselective synthesis of 1-aryl-tetrahydroisoquinolines through iridium catalyzed asymmetric hydrogenation

Asymmetric hydrogenation of 1-aryl-3,4-dihydroisoquinolines using the [IrCODCl]2/(R)-3,5-diMe-Synphos catalyst is reported. Under mild reaction conditions, this atom-economical process provides easy access to a variety of enantioenriched 1-aryl-1,2,3,4-tetrahydroisoquinoline derivatives, which are important pharmacophores found in several pharmaceutical drug candidates, in high yields and enantiomeric excesses up to 99% after a single crystallization.