221148-45-4

Basic information

• Product Name: 3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine
• Synonyms: 3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine
• CAS NO: 221148-45-4
• Molecular Weight: 379.439
• Mol File: 221148-45-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine(221148-45-4)
• EPA Substance Registry System: 3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine(221148-45-4)

Safety Data

• Hazardous Substances Data: 221148-45-4(Hazardous Substances Data)

Upstream product

• 497-19-8 sodium carbonate 
• 149104-88-1 4-methanesulphonylphenylboronic acid 
• 781674-50-8 2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester 
• 781674-57-5 2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid 
• 7515-17-5 methyl 3-(4-methoxyphenyl)propynoate 

Downstream Products

• 221148-25-0 4-[3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-bl]pyridazin-2-yl]-phenol 
• 221148-46-5 2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine 

Relevant articles and documents

USE OF CYCLOOXYGENASE-2 INHIBITORS FOR THE TREATMENT OF DEPRESSIVE DISORDERS

The invention concerns the use of compounds of formula (I), (II) and (III): which are COX-2 (cyclooxygenase-2) inhibitors, and pharmaceutically acceptable salts or solvates thereof, for the treatment of depressive disorders in combination with an effective amount of a second component which is a selective serotonin reuptake inhibitor.

2,3-Diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2(COX-2) inhibitors

The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(C