781674-50-8

Basic information

• Product Name: 2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester
• Synonyms: 2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester
• CAS NO: 781674-50-8
• Molecular Weight: 283.287
• Mol File: 781674-50-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester(781674-50-8)
• EPA Substance Registry System: 2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine-3-carboxylic acid methyl ester(781674-50-8)

Safety Data

• Hazardous Substances Data: 781674-50-8(Hazardous Substances Data)

Upstream product

• 7515-17-5 methyl 3-(4-methoxyphenyl)propynoate 

Downstream Products

• 221148-45-4 3-(4-methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-pyrazolo[1,5-b]pyridazine 
• 221148-46-5 2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine 
• 221148-48-7 2-(4-difluoromethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-b]pyridazine 
• 221148-25-0 4-[3-(4-methanesulfonyl-phenyl)-pyrazolo[1,5-bl]pyridazin-2-yl]-phenol 

Relevant articles and documents

USE OF CYCLOOXYGENASE-2 INHIBITORS FOR THE TREATMENT OF DEPRESSIVE DISORDERS

The invention concerns the use of compounds of formula (I), (II) and (III): which are COX-2 (cyclooxygenase-2) inhibitors, and pharmaceutically acceptable salts or solvates thereof, for the treatment of depressive disorders in combination with an effective amount of a second component which is a selective serotonin reuptake inhibitor.

2,3-Diaryl-pyrazolo[1,5-b]pyridazines derivatives, their preparation and their use as cyclooxygenase 2(COX-2) inhibitors

The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(C