222054-67-3

Basic information

• Product Name: 1-Methoxy-4-((Z)-2-nitro-vinyl)-2-[4-((E)-2-nitro-vinyl)-phenoxy]-benzene
• Synonyms: 1-Methoxy-4-((Z)-2-nitro-vinyl)-2-[4-((E)-2-nitro-vinyl)-phenoxy]-benzene
• CAS NO: 222054-67-3
• Molecular Weight: 342.308
• Mol File: 222054-67-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Methoxy-4-((Z)-2-nitro-vinyl)-2-[4-((E)-2-nitro-vinyl)-phenoxy]-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methoxy-4-((Z)-2-nitro-vinyl)-2-[4-((E)-2-nitro-vinyl)-phenoxy]-benzene(222054-67-3)
• EPA Substance Registry System: 1-Methoxy-4-((Z)-2-nitro-vinyl)-2-[4-((E)-2-nitro-vinyl)-phenoxy]-benzene(222054-67-3)

Safety Data

• Hazardous Substances Data: 222054-67-3(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 2748-98-3 3-(4-formylphenoxy)-4-methoxybenzaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 
• 621-59-0 isovanillin 

Downstream Products

• 222054-69-5 2-{3-[4-(2-amino-ethyl)-phenoxy]-4-methoxy-phenyl}-ethylamine 

Relevant articles and documents

Entropically favorable macrolactamization. Synthesis of isodityrosine peptide analogues by tandem Erlenmeyer condensation-macrolactamization

Macrolactams containing a modified isodityrosine moiety were assembled by direct addition of a bis-4-aryliden-5(4H)-oxazolone, derived by double Erlenmeyer condensation of diaryl ether dicarboxaldehydes and an α,ω- diamine, derived from the same precursor. Tandem acylation of diamines with the bis-Erlenmeyer oxazolone gave macrolactams in yields of up to 30%. TECM demonstrates an entropically controlled 28-membered ring closure and allows rapid access to a variety of cyclic isodityrosine peptide analogues of the biologically active natural product bastadin-5.