22258-71-5

Basic information

• Product Name: 3-(2-chloroethyl)-1,3-benzothiazol-2(3H)-one
• Synonyms: 2(3H)-benzothiazolone, 3-(2-chloroethyl)-; 3-(2-Chloroethyl)-1,3-benzothiazol-2(3H)-one; 3-(2-Chloro-ethyl)-3H-benzothiazol-2-one
• CAS NO: 22258-71-5
• Molecular Formula: C₉H₈ClNOS
• Molecular Weight: 213.6839
• Mol File: 22258-71-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 355°C at 760 mmHg
• Flash Point: 168.5°C
• Density: 1.382g/cm³
• Vapor Pressure: 3.22E-05mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: 3-(2-chloroethyl)-1,3-benzothiazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chloroethyl)-1,3-benzothiazol-2(3H)-one(22258-71-5)
• EPA Substance Registry System: 3-(2-chloroethyl)-1,3-benzothiazol-2(3H)-one(22258-71-5)

Safety Data

• Hazardous Substances Data: 22258-71-5(Hazardous Substances Data)

Upstream product

• 21344-50-3 3-(β-hydroxyethyl)benzothiazolin-2-one 
• 136-95-8 2-amino-benzthiazole 
• 107-07-3 2-chloro-ethanol 
• 16954-69-1 2-methylaminobenzthiazole 
• 28291-69-2 2-ethylaminobenzothiazole 
• 18392-47-7 2-β-hydroxyethylaminobenzothiazole 
• 934-34-9 2(3H)-Benzothiazolone 
• 107-04-0 1-Bromo-2-chloroethane 
• 624-70-4 1-chloro-2-iodoethane 
• 934-34-9 2-hydroxybenzothiazole 

Relevant articles and documents

On interaction of 2-amino-benzothiazoles with halohydrins

Interaction of 2-aminobenzothiazoles with ethylene chlorohydrin on boiling leads mainly to formation of the corresponding 3-(β-chloroethyl)benzothiazolin-2-ones. Reducing the reaction temperature increases the fraction of 2-imino-(3-β-hydroxyethyl)benzothiazolines. In both instances formation of bis[3-(β-hydroxyethyl)benzothiazol-2-ylidene]ammonium chlorides is observed. The reaction of 2-aminobenzothiazole with propylene bromohydrin gives only the corresponding amino alcohols. The anomalous products from the reaction of β-chloroethyl derivatives of benzothiazolinones result from a dominating side reaction of the starting 2-aminobenzothiazoles with the ethylene chlorohydrin thermolysis products that are formed on boiling. 1999 KluwerAcademic/Plenum Publishers.

Benzimidazolidinone derivatives as muscarinic agents

Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.

BEHAVIOR OF ETHYLENE CHLOROHYDRIN IN REACTIONS WITH 2-AMINOBENZOTHIAZOLES

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