223677-02-9Relevant articles and documents
SSAO INHIBITORS AND USE THEREOF
-
Paragraph 00388, (2021/05/07)
Provided are a compound of formula (I') or (I), a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of SSAO, a pharmaceutical composition comprising a compound of formula (I') or (I), and a method of treating or preventing a disease in which SSAO plays a role.
Design and synthesis of thiol containing inhibitors of matrix metalloproteinases
Fink, Cynthia A.,Carlson, J. Eric,Boehm, Charles,McTaggart, Patricia,Qiao, Ying,Doughty, John,Ganu, Vishwas,Melton, Richard,Goldberg, Ronald
, p. 195 - 200 (2007/10/03)
A series of thiol containing derivatives was prepared. Several of these compounds were found to inhibit matrix metalloproteinases 1, 3, and 9 with selectivity towards 3 and 9. Compounds 15, 20 and 22 were administered to rats orally at 75 μmol/kg. Drug levels of compounds 20 and 22 in the plasma were found to exceed the IC50 values for MMP 3 and 9 four hours after administration.