2243-27-8Relevant articles and documents
Brown,Jenkins
, p. 458 (1976)
EFFET DE L'EAU ET D'AUTRES ADDITIFS SUR L'ALKYLATION DE KCN EN TRANSFERT DE PHASE SOLIDE-LIQUIDE SANS SOLVANT.
Bram, G.,Loupy, A.,Pedoussaut, M.
, p. 4171 - 4174 (1986)
The alkylation of KCN by solid-liquid phase transfer catalysis without added solvent is optimal when a definite amount of water is added.The efficiencies of ten other additives are compared with those of water.
Barrett,Grattan
, p. 4237 (1979)
Mechanisms of Polymer-Supported Catalysis. 1. Reaction of 1-Bromooctane with Aqueous Sodium Cyanide Catalyzed by Polystyrene-Bound Benzyltri-n-butylphosphonium Ion
Tomoi, M.,Ford, Warren T.
, p. 3821 - 3828 (1981)
The rate of reaction of 1-bromooctane with aqueous sodium cyanide catalyzed by insoluble polystyrene-bound benzyltri-n-butylphosphonium salts has been studied as a function of the method of mixing of the triphase system, catalyst particle size, degree of polymer cross-linking, solvent, and temperature.Reaction rates increase as the speed of mechanical stirring increases to a maximum rate at 600 rpm.Turbulent vibromixing and ultrasonic mixing do not cause any additional reaction rate increase.Reaction rates increase as catalyst particle sizes decrease, even at the maximum stirring speed.Reaction rates decrease as percent of divinylbenzene cross-linking in the polymer increases from 2percent to 10percent.Reaction rates increase with increasing swelling power of the solvent in the order decane /= 28 times faster than polymer-bound benzyltrimethylammonium when mass transfer and intraparticle diffusion do not limit the rates.
TRIPHASE CATALYSIS OF POLYMER-BOUND AMINE OXIDE IN CYANIDE DISPLACEMENT ON 1-BROMOOCTANE
Maeda, Hirokazu,Hayashi, Yoshiyuki,Teramura, Kazuhiro
, p. 677 - 678 (1980)
Cross-linked polystyrene supported tertiary amines and amine oxides are found to be a very efficient catalyst for a nucleophilic substitution reaction.The amine oxide resin (MPE-5-AO) was one of the most effective and economical catalysts and can be used several times without the loss of the catalytic activity.
Regen
, p. 5956 (1975)
Ni-Catalyzed Isomerization-Hydrocyanation Tandem Reactions: Access to Linear Nitriles from Aliphatic Internal Olefins
Gao, Jihui,Ni, Jie,Yu, Rongrong,Cheng, Gui-Juan,Fang, Xianjie
supporting information, p. 486 - 490 (2021/02/05)
A highly regioselective nickel-based catalyst system for the isomerization/hydrocyanation of aliphatic internal olefins is described. This benign tandem reaction provides facile access to a wide variety of aliphatic nitriles in good yields with excellent regioselectivities. Thanks to Lewis acid-free conditions, the protocol features board functional groups tolerance, including secondary amine and unprotected alcohol groups.
Synthetic Fuels from Biomass: Photocatalytic Hydrodecarboxylation of Octanoic Acid by Ni Nanoparticles Deposited on TiO2
Albero, Josep,Du, Xiangze,García, Hermenegildo,Hu, Changwei,Li, Dan,Peng, Yong
, (2021/12/13)
Decarboxylation of low-value fatty acids from biomass is a simple process to produce synthetic fuels suitable to be blended with gasoline or diesel. The present study reports the photocatalytic decarboxylation of octanoic acid in the presence of H2 by a series of modified TiO2 to form mixtures of n-heptane and tetradecane as major products in variable proportions, depending on the photocatalyst and the reaction conditions. It was found that the photocatalytic activity increases upon an optimal reductive NaBH4 treatment, presumably by generation of surface oxygen vacancies and by the deposition of Ni nanoparticles in the appropriate loading. Under the optimized conditions, an almost complete octanoic acid conversion and a combined selectivity to n-heptane and tetradecane over 80 % were reached at 10 h of UV/Vis light irradiation with a 300 W Xe lamp. No changes in the photocatalytic performance were observed for six consecutive runs. The present results illustrate the possibility that photocatalytic decarboxylation offers for the transformation of biomass into synthetic fuels under mild conditions.
Design, synthesis and antiparasitic evaluation of click phospholipids
Afroudakis, Pantelis,Barrias, Emile,Bifeld, Eugenia,Borsari, Chiara,Calogeropoulou, Theodora,Clos, Joachim,Costi, Maria Paola,Ellinger, Bernhard,Fotopoulou, Theano,Fragiadaki, Irini,Georgikopoulou, Kalliopi,Gul, Sheraz,Hachenberg, Julia,Kuzikov, Maria,Magoulas, George E.,Prousis, Kyriakos C.,Roussaki, Marina,Santarem, Nuno,Scoulica, Effie,Tejera Nevado, Paloma,da Silva, Anabela Cordeiro,de Souza, Wanderley
, (2021/07/26)
A library of seventeen novel ether phospholipid analogues, containing 5-membered heterocyclic rings (1,2,3-triazolyl, isoxazolyl, 1,3,4-oxadiazolyl and 1,2,4-oxadiazolyl) in the lipid portion were designed and synthesized aiming to identify optimised miltefosine analogues. The compounds were evaluated for their in vitro antiparasitic activity against Leishmania infantum and Leishmania donovani intracellular amastigotes, against Trypanosoma brucei brucei and against different developmental stages of Trypanosoma cruzi. The nature of the substituents of the heterocyclic ring (tail) and the oligomethylene spacer between the head group and the heterocyclic ring was found to affect the activity and toxicity of these compounds leading to a significantly improved understanding of their structure–activity relationships. The early ADMET profile of the new derivatives did not reveal major liabilities for the potent compounds. The 1,2,3-triazole derivative 27 substituted by a decyl tail, an undecyl spacer and a choline head group exhibited broad spectrum antiparasitic activity. It possessed low micromolar activity against the intracellular amastigotes of two L. infantum strains and T. cruzi Y strain epimastigotes, intracellular amastigotes and trypomastigotes, while its cytotoxicity concentration (CC50) against THP-1 macrophages ranged between 50 and 100 μM. Altogether, our work paves the way for the development of improved ether phospholipid derivatives to control neglected tropical diseases.
