74478-11-8

Basic information

• Product Name: 1-Nonanone, 1-(2,4,6-trihydroxyphenyl)-
• CAS NO: 74478-11-8
• Molecular Formula: C15H22O4
• Molecular Weight: 266.337
• Mol File: 74478-11-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Nonanone, 1-(2,4,6-trihydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Nonanone, 1-(2,4,6-trihydroxyphenyl)-(74478-11-8)
• EPA Substance Registry System: 1-Nonanone, 1-(2,4,6-trihydroxyphenyl)-(74478-11-8)

Safety Data

• Hazardous Substances Data: 74478-11-8(Hazardous Substances Data)

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 764-85-2 Nonanoyl chloride 
• 2243-27-8 nonanonitrile 

Downstream Products

• 96756-05-7 3-n-nonyl-2,4,6-trihydroxyacetophenone 
• 96756-21-7 2-Nonyl-benzene-1,3,5-triol 

Relevant articles and documents

Structural optimization and antibacterial evaluation of rhodomyrtosone B analogues against MRSA strains

Methicillin-resistant Staphylococcus aureus (MRSA) infections are well-known as a significant global health challenge. In this study, twenty-two congeners of the natural antibiotic rhodomyrtosone B (RDSB) were synthesized with the aim of specifically enhancing the structural diversity through modifying the pendant acyl moiety. The structure-activity relationship study against various MRSA strains revealed that a suitable hydrophobic acyl tail in the phloroglucinol scaffold is a prerequisite for antibacterial activity. Notably, RDSB analogue 11k was identified as a promising lead compound with significant in vitro and in vivo antibacterial activities against a panel of hospital mortality-relevant MRSA strains. Moreover, compound 11k possessed other potent advantages, including breadth of the antibacterial spectrum, rapidity of bactericidal action, and excellent membrane selectivity. The mode of action study of compound 11k at the biophysical and morphology levels disclosed that 11k exerted its MRSA bactericidal action by membrane superpolarization resulting in cell lysis and membrane disruption. Collectively, the presented results indicate that the novel modified RDSB analogue 11k warrants further exploration as a promising candidate for the treatment of MRSA infections.

Antifungal Activities of 2,4,6-Trihydroxyacylophenones and Related Compounds

The antifungal activities of sixty two 2,4,6-trihydroxyacylophenones and related compounds against Trichophyton spp. and other fungi were investigated to study their structure-activity relationship.It was found that the activities of these compounds were closely related to the length of the acyl and alkyl chains attached to the 1,3,5-trihydroxybenzene moiety.Among the compounds tested, 2,4,6-trihydroxy-3-nonylacetophenone (V-7) showed the highest activity against Trichophyton spp., with MICs being 1.57 μg/ml, and was more active than amphotericin B.