22446-57-7

Basic information

• Product Name: 3-(4-methoxy-3-methylphenyl)propanenitrile
• Synonyms: 3-(4-methoxy-3-methylphenyl)propanenitrile
• CAS NO: 22446-57-7
• Molecular Weight: 175.23
• Mol File: 22446-57-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-methoxy-3-methylphenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxy-3-methylphenyl)propanenitrile(22446-57-7)
• EPA Substance Registry System: 3-(4-methoxy-3-methylphenyl)propanenitrile(22446-57-7)

Safety Data

• Hazardous Substances Data: 22446-57-7(Hazardous Substances Data)

Upstream product

• 87776-77-0 2-(4-methoxy-3-methylphenyl)ethanol 
• 14804-31-0 2-methyl-4-bromoanisole 
• 75581-11-2 1-iodo-4-methoxy-3-methylbenzene 
• 578-58-5 2-methylmethoxybenzene 
• 107-13-1 acrylonitrile 
• 69919-95-5 2-(3-methyl-4-methoxyphenyl)ethyl bromide 
• 143-33-9 sodium cyanide 

Downstream Products

• 1132077-58-7 3-(3-bromo-4-methoxy-5-methylphenyl)propanenitrile 
• 22516-99-0 3-(4-hydroxy-3-methylphenyl)propanenitrile 
• 130593-47-4 2,3,5,6-Tetrakis-[2-(4-methoxy-3-methyl-phenyl)-ethyl]-pyrazine 
• 856603-84-4 3-(4-methoxy-3-methyl-phenyl)-propionic acid methyl ester 

Relevant articles and documents

Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction

(Chemical Equation Presented) HDM2 regulates p53 by binding to its transactivation domain and promoting its ubiquitin-dependent degradation. Crystallographic analysis of the HDM2/p53 complex revealed that three hydrophobic residues (F19, W23, L26) along one face of the p53 helical peptide are essential for binding (see picture). Terphenyl-based antagonists mimic the α-helical region of p53 and disrupt HDM2/p53 complexation.