2251-82-3

Basic information

• Product Name: 1-(difluoromethyl)-4-(trifluoromethyl)benzene
• Synonyms: 1-(difluoromethyl)-4-(trifluoromethyl)benzene
• CAS NO: 2251-82-3
• Molecular Weight: 196.12
• Mol File: 2251-82-3.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 1-(difluoromethyl)-4-(trifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(difluoromethyl)-4-(trifluoromethyl)benzene(2251-82-3)
• EPA Substance Registry System: 1-(difluoromethyl)-4-(trifluoromethyl)benzene(2251-82-3)

Safety Data

• Hazardous Substances Data: 2251-82-3(Hazardous Substances Data)

Upstream product

• 2925-22-6 2,2-difluoroacetyl fluoride 
• 501374-30-7 5,5-dimethyl-2-(4-trifluoromethyl-phenyl)-[1,3,2]dioxaborinane 
• 56228-54-7 2-((difluoromethyl)sulfonyl)-4,6-dimethylpyrimidine 
• 214360-65-3 4-trifluoromethylphenylboronic acid pinacol ester 
• 73789-96-5 ethyl α,α-difluoro-4-(trifluoromethyl)benzeneacetate 
• 1493-03-4 iododifluoromethane 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 65864-64-4 trimethyl(difluoromethyl)silane 
• 98-56-6 4-chlorobenzotrifluoride 
• 1511-62-2 bromodifluoromethane 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 75-10-5 Difluoromethane 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 858344-44-2 bis[4-(trifluoromethyl)phenyl]zinc 

Downstream Products

• 2251-60-7 1-(bromodifluoromethyl)-4-(trifluoromethyl)benzene 
• 433-19-2 1,4-bis(trifluoromethyl)benzene 
• 114467-78-6 1-(Difluoro-phenylsulfanyl-methyl)-4-trifluoromethyl-benzene 
• 114467-82-2 1-(Difluoro-phenoxy-methyl)-4-trifluoromethyl-benzene 
• 114467-87-7 1-(Azido-difluoro-methyl)-4-trifluoromethyl-benzene 

Relevant articles and documents

A new C-F bond-cleavage route for the synthesis of octafluoro[2.2]paracyclophane

-

Iron-Catalyzed Fluoroalkylation of Arylborates with Sulfone Reagents: Beyond the Limitation of Reduction Potential

The iron-catalyzed alkyl–aryl coupling reaction between sulfones and arylboron compounds has remained a challenge. We report the first iron-catalyzed radical difluoroalkylation of arylborates with N-heteroaryl sulfones. The coordination between the iron catalyst and the nitrogen atom of N-heteroaryl sulfones was identified to be important in overcoming the reduction potential limitation of sulfones in the intermolecular single-electron-transfer process, which enables both fluoroalkyl N-heteroaryl sulfones (with relatively high reduction potentials) and nonfluorinated alkyl N-heteroaryl sulfones (with low reduction potentials) to serve as powerful alkylation reagents.

Difluoromethyl-substituted compound (by machine translation)

[Problem] to provide a, simple and inexpensive manufacturing method is difluoromethyl substituted compounds using a reagent. [Solution] a method for producing a compound using a catalyst [...] difluoromethyl-substituted,(I) the catalyst, a nickel compound and nitrogen in the bidentate ligand, raw Ar a-Z " in the formula, the Ar, substituted or unsubstituted aryl group or a substituted or unsubstituted 5 - 10 membered heteroaryl group C6 a-14, Z is, (OR) B2 Or a group represented by a is represented MgX. " Compound represented, difluoromethyl-substituted compounds, Ar e CF2 A method for producing a compound represented by H, or(II) catalyst, a palladium compound and a diphosphine ligand, raw material is Q-a B (OR1 )2 " In the formula, Q is, substituted or unsubstituted aryl C6 a-10, 5 - 10 membered heteroaryl or substituted or unsubstituted, or Ar1 A group represented by - CH=CH - shown. R1 Is, a hydrogen atom or an alkyl group C1 a-6. " Compounds, a compound represented by Q-a Zn-to-Q or, difluoromethyl-substituted compounds, Q-to-CF2 A method for producing a compound represented by H. [Drawing] no (by machine translation)