22518-01-0

Basic information

• Product Name: 3-hydroxy-4-isopropylbenzyl alcohol diisobutyrate
• CAS NO: 22518-01-0
• Molecular Weight: 306.402
• Mol File: 22518-01-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-4-isopropylbenzyl alcohol diisobutyrate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-4-isopropylbenzyl alcohol diisobutyrate(22518-01-0)
• EPA Substance Registry System: 3-hydroxy-4-isopropylbenzyl alcohol diisobutyrate(22518-01-0)

Safety Data

• Hazardous Substances Data: 22518-01-0(Hazardous Substances Data)

Upstream product

• 77311-67-2 3-Acetoxy-4-isopropylbenzoic acid 
• 528-79-0 2-isopropyl-5-methylphenyl acetate 
• 77878-31-0 7-acetoxymethyl-4-methylcoumarin 
• 59555-33-8 3-acetoxy-4-isopropyl-benzyl acetate 
• 53878-05-0 7-bromomethyl-4-methylcoumarin 
• 77311-68-3 5-(hydroxymethyl)-2-(1-methylethyl)phenol 
• 79-30-1 isobutyryl chloride 
• 97-72-3 2-Methylpropionic anhydride 

Relevant articles and documents

Synthesis of Two Naturally Ocurring Isobutyrates Related to Thymol

7-Acetoxymethylcoumarin (15), prepared by heating 7-bromomethyl-4-methylcoumarin (14) with sodium acetate and acetic acid, on heating with NaOH-ethylene glycol, furnishes 3-hydroxy-4-isopropylbenzyl alcohol (3).Compound (3) has been transformed into diisobutyrate (1) of 3-hydroxy-4-isopropylbenzyl alcohol.Selective methylation of 3 furnishes 4-isopropyl-3-methoxybenzyl alcohol (5), an intermediate for the synthesis of sempervirol.Acylation of 5 gives the naturally ocurring 4-isopropyl-3-methoxybenzyl isobutyrate (2). 4,7-Dimethylcoumarin affords o-isopropenylphenol (7) when heated with aq.NaOH at 140 deg C, but if the reaction is carried out at 210 deg C the product formed is m-cresol (17).