2264-12-2

Basic information

• Product Name: 1H-Benzimidazole, 2-(4-fluorophenyl)-1-[(4-fluorophenyl)methyl]-
• CAS NO: 2264-12-2
• Molecular Formula: C20H14F2N2
• Molecular Weight: 320.341
• Mol File: 2264-12-2.mol
• Article Data: 54

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole, 2-(4-fluorophenyl)-1-[(4-fluorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole, 2-(4-fluorophenyl)-1-[(4-fluorophenyl)methyl]-(2264-12-2)
• EPA Substance Registry System: 1H-Benzimidazole, 2-(4-fluorophenyl)-1-[(4-fluorophenyl)methyl]-(2264-12-2)

Safety Data

• Hazardous Substances Data: 2264-12-2(Hazardous Substances Data)

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 20 carbon (C) atoms, 13 hydrogen (H) atoms, 2 fluorine (F) atoms, and 3 nitrogen (N) atoms.

Explanation

The compound is derived from the benzimidazole core structure, which is a fused ring system containing both benzene and imidazole rings. It has two fluorophenyl groups attached to it, which are phenyl rings with a fluorine atom in the 4-position.

Explanation

Benzimidazole derivatives are known for their various biological activities, making them valuable in the development of new drugs and therapies.

Explanation

The compound may exhibit these properties due to its benzimidazole core structure and the presence of fluorophenyl groups, which can influence its interactions with biological targets.

Explanation

The fluorine atoms in the 4-position of the phenyl groups can contribute to the compound's pharmacological properties and bioavailability, as fluorine is known to modulate the properties of organic compounds.

Explanation

While the compound has potential applications in medicinal chemistry and pharmaceutical research, more studies are required to determine its specific uses and effectiveness in various biological and pharmaceutical applications.

Structure

Benzimidazole derivative with two fluorophenyl groups

Potential Applications

Medicinal chemistry and pharmaceutical research

Biological Activities

Anti-cancer, anti-inflammatory, and anti-microbial properties

Presence of Fluorine Atoms

In the 4-position of the phenyl group

Further Research

Needed to fully understand potential uses

Upstream product

• 459-56-3 4-fluorobenzylic alcohol 
• 95-54-5 1,2-diamino-benzene 
• 134227-41-1 1-(4-fluorophenyl)-N-[(4-fluorophenyl)methyl]methanamine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 88-74-4 2-nitro-aniline 
• 7191-70-0 N-(4''-fluorobenzyl)-1,2-phenylenediamine 
• 459-46-1 4-Fluorobenzyl bromide 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 1239692-19-3 [iridium(III)chloride(1-(4-fluorobenzyl)-2-(4-fluorophenyl)-1H-benzo[d]imidazole)2]2 
• 1239692-18-2 Ir(1-(4-fluorobenzyl)-2-(4-fluorophenyl)-1-H-benzo[d]imidazole)((3-pyridin-2-yl)4,5,6,7-tetrahydro-2H-indazole) 

Relevant articles and documents

Computational studies of 1,2-disubstituted benzimidazole derivatives

Some 1,2-disubstituted benzimidazole derivatives (1-6) have been synthesized and characterized by mass, 1H, 13C NMR and elemental analysis. XRD analysis was carried out for 1-(4-methylbenzyl)-2-p- tolyl-1H-benzo[d]imidazole. Calculat

Synthesis, spectral studies and solvatochromism of some novel benzimidazole derivatives-ESIPT process

Some novel benzimidazole derivatives were synthesized and characterized by 1H, 13C NMR mass and elemental analysis. XRD analysis was carried out for 1-(4-methylbenzyl)-2-p-tolyl-1H-benzo[d]imidazole. The solvent effect on the absorpt

A facile and highly chemoselective synthesis of 1,2-disubstituted benzimidazoles using hierarchical nanoporous material

A highly ordered nanoporous aluminosilicate (MMZY) is prepared and employed as a catalyst for the synthesis of benzimidazoles from 1,2-diaminobenzene and aromatic aldehydes. In all the cases, the reactions are highly chemoselective and afford 1,2-disubstituted benzimidazoles in excellent yield. The catalyst was characterized by electron microscopy and X-ray methods and its other advantages like functional tolerance, mildness of the reaction conditions, easy separation, and reusability are also highlighted.

Effective fluorescent chemosensors for the detection of Zn2+ metal ion

Benzimidazole derivatives synthesized from three components assembling condensation reaction behaves as a selective fluorescent sensor for Zn 2+ metal ion. These benzimidazole derivatives were characterized by 1H, 13C NMR,

An efficient facile and one-pot synthesis of benzodiazepines and chemoselective 1,2-disubstituted benzimidazoles using a magnetically retrievable Fe3O4 nanocatalyst under solvent free conditions

Benzodiazepine and chemoselective 1,2-disubstituted benzimidazole derivatives were synthesized by the condensation reaction of o-phenylenediamine with ketones and aryl aldehydes using Fe3O4 nanoparticles as a recyclable catalyst unde

Water extract of onion catalyst: An economical green route for the synthesis of 2-substituted and 1,2-disubstituted benzimidazole derivatives with high selectivity

An efficient, environmental friendly and substrate controlled method of synthesis of 2-substituted benzimidazole derivatives 3 and 1,2-disubstituted benzimidazole derivatives 4 with high selectivity has been achieved from the reaction of o-phenylenediamine 1 and aldehydes 2 in the presence of water extract of onion and selecting suitable reaction medium. This method is widely applicable for variety of aldehydes such as aromatic/aliphatic/heterocyclic aldehydes and 1,2-diamines to afford 2-substituted benzimidazole derivatives 3 and 1,2-disubstituted benzimidazole derivatives 4 in good to excellent yields (up to 96%). The developed method of water extract of onion catalysis produced 2-substituted benzimidazoles 3 from aromatic aldehydes having electron-withdrawing groups, whereas aromatic aldehydes bearing electron donating groups selectively furnished 1,2-disubstituted benzimidazole 4 derivatives. The process described here has several advantages of cheap, low energy consumption, commercially available starting materials, operational simplicity and nontoxic catalyst. The use of water extract of onion makes this present methodology green and giving a useful contribution to the existing methods available for the preparation of benzimidazole derivatives. In addition, Hammett correlation of substituent constant (σ) vs percentage (%) yield has been established.

Nickel catalyzed sustainable synthesis of benzazoles and purines: Via acceptorless dehydrogenative coupling and borrowing hydrogen approach

Herein we report nickel-catalyzed sustainable synthesis of a few chosen five-membered fused nitrogen heterocycles such as benzimidazole, purine, benzothiazole, and benzoxazole via acceptorless dehydrogenative functionalization of alcohols. Using a bench stable, easy to prepare, and inexpensive Ni(ii)-catalyst, [Ni(MeTAA)] (1a), featuring a tetraaza macrocyclic ligand (tetramethyltetraaza[14]annulene (MeTAA)), a wide variety of polysubstituted benzimidazole, purine, benzothiazole, and benzoxazole derivatives were prepared via dehydrogenative coupling of alcohols with 1,2-diaminobenzene, 4,5-diaminopyrimidine, 2-aminothiphenol, and 2-aminophenol, respectively. A wide array of benzimidazoles were also prepared via a borrowing hydrogen approach involving alcohols as hydrogen donors and 2-nitroanilines as hydrogen acceptors. A few control experiments were performed to understand the reaction mechanism.

Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation

Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ethan