226908-63-0

Basic information

• Product Name: 6-Amino-9-benzyl-2-(2-hydroxyethoxy)-9H-purin-6-amine
• Synonyms: 6-Amino-9-benzyl-2-(2-hydroxyethoxy)-9H-purin-6-amine
• CAS NO: 226908-63-0
• Molecular Weight: 285.305
• Mol File: 226908-63-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-Amino-9-benzyl-2-(2-hydroxyethoxy)-9H-purin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Amino-9-benzyl-2-(2-hydroxyethoxy)-9H-purin-6-amine(226908-63-0)
• EPA Substance Registry System: 6-Amino-9-benzyl-2-(2-hydroxyethoxy)-9H-purin-6-amine(226908-63-0)

Safety Data

• Hazardous Substances Data: 226908-63-0(Hazardous Substances Data)

Upstream product

• 56046-25-4 6-amino-9-benzyl-2-chloropurine 
• 7674-36-4 9-Benzylpurine-2,6-diamine 
• 7674-33-1 6-Amino-9-benzyl-9H-purin-2(3H)-one 
• 7388-28-5 sodium 2-hydroxyethoxide 
• 96-49-1 [1,3]-dioxolan-2-one 

Downstream Products

• 226908-65-2 6-Amino-9-benzyl-2-(2-hydroxyethoxy)-8-methoxypurine 
• 226908-64-1 6-Amino-9-benzyl-8-bromo-2-(2-hydroxyethoxy)purine 

Relevant articles and documents

Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities

In order to create novel compounds which possess potent interferon (IFN) inducing activities with excellent oral bioavailabilities, a series of 8-hydroxyadenines, which have various alkoxy or alkylthio moieties at the adenine C(2)-position, were synthesiz

Synthesis of acyclic nucleotide analogues derived from N3-substituted isoguanine

Reaction of 9-benzyl-6-{[(dimethylamino)methylidene]amino}purin-2(3H)-one (7) with ethylene carbonate gave a mixture of 9-benzyl-2-(2-hydroxyethoxy)purin-6-amine (10) and 2-amino-9-benzyl-3-(2-hydroxyethyl)purin-2(3H)-one (11). This mixture reacted with diisopropyl (tosyloxymethyl)phosphonate in the presence of NaH followed by catalytic hydrogenation and bromotrimethylsilane treatment to afford isomeric 6-amino-3-[2-(phosphonomethoxy)ethyl]purin-2(3H)-one (3) and 2-[2-(phosphonomethoxy)ethoxy]purin-6-amine (15). Similar treatment of compound 7 with tritylglycidol gave two isomeric 2-hydroxy-3-(trityloxy)propyl derivatives 18, 20 which were subsequently condensed with diisopropyl (tosyloxymethyl)phosphonate to afford protected diester intermediates 21 and 22; these compounds were transformed by hydrogenolysis and ester cleavage with bromotrimethylsilane to the isomeric 6-amino-3-[3-hydroxy-2-(phosphonomethoxy)propyl]-purin-2(3H)-one (2) and 2-[3-hydroxy-2-(phosphonomethoxy)propoxy]purin-6-amine (24). None of the free phosphonates 2, 3, 15 or 24 exhibited any antiviral or cytostatic activity.