7674-36-4

Basic information

• Product Name: 9-benzyl-9H-purine-2,6-diamine
• CAS NO: 7674-36-4
• Molecular Formula: C₁₂H₁₂N₆
• Molecular Weight: 240.2639
• Mol File: 7674-36-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 596.5°C at 760 mmHg
• Flash Point: 314.5°C
• Density: 1.51g/cm³
• Vapor Pressure: 3.42E-14mmHg at 25°C
• Refractive Index: 1.788
• CAS DataBase Reference: 9-benzyl-9H-purine-2,6-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-benzyl-9H-purine-2,6-diamine(7674-36-4)
• EPA Substance Registry System: 9-benzyl-9H-purine-2,6-diamine(7674-36-4)

Safety Data

• Hazardous Substances Data: 7674-36-4(Hazardous Substances Data)

Upstream product

• 68462-61-3 ethyl 5‐amino‐1‐benzyl‐1H‐imidazole‐4‐carboxylate 
• 228263-00-1 9-benzyl-2,6-bis(ethoxycarbonyl)purine 
• 228262-99-5 5-amino-1-benzyl-4-imidazolecarboxylic acid 
• 56046-25-4 6-amino-9-benzyl-2-chloropurine 
• 50-01-1 guanidine hydrochloride 
• 60598-48-3 5-amino-1-benzyl-1H-imidazole-4-carbonitrile 
• 6336-42-1 2-amino-9-benzyl-6-chloro-9H-purine 
• 100-39-0 benzyl bromide 
• 10310-21-1 2-Amino-6-chloropurin 
• 1904-98-9 2,6-diaminopurine 
• 5451-40-1 2,6 dichloropurine 
• 1839-18-5 2-chloroadenine 

Downstream Products

• 226908-04-9 2,6-diamino-9-benzyl-8-bromopurine 
• 328378-73-0 6-Amino-9-benzyl-3-{2-[(diisopropyloxyphosphoryl)methoxy]ethyl}-9H-purin-2(3H)-one 
• 328378-72-9 9-Benzyl-2{2-[(diisopropyloxyphosphoryl)methoxy]ethoxy}-9H-purin-6-amine 
• 226908-63-0 6-Amino-9-benzyl-2-(2-hydroxyethoxy)-9H-purin-6-amine 
• 226908-43-6 2-amino-9-benzyl-8-hydroxyadenine 
• 226907-93-3 6-Amino-9-benzyl-2-butylaminopurine 
• 7674-33-1 6-Amino-9-benzyl-9H-purin-2(3H)-one 

Relevant articles and documents

8-Bromination of 2,6,9-trisubstituted purines with pyridinium tribromide

2,6,9-Trisubstituted purines are brominated in high yields using pyridinium tribromide as the brominating reagent. This procedure works excellently for electron-rich purines having electron-donating substituents at the 2- and 6-positions. The use of pyridinium tribromide, a crystalline alternative to elemental bromine, improves the bromination procedure for this type of substrate as the reagent is easy to handle and the work-up and purification procedures are simplified.

Synthesis and structure-activity relationships of 2-amino-8- hydroxyadenines as orally active interferon inducing agents

Recently, we have reported the 8-hydroxyadenine derivatives (2-4) as a novel class of interferon (IFN) inducing agents. In the present study, a series of 8-hydroxyadenines, which possess various amino moieties at the adenine C(2)-position, were synthesized and evaluated for their ability to induce endogenous IFN in comparison to the known active agent, Imiquimod. Among the compounds prepared, compound 9o possessing a 2-methoxyethylamino group at C(2)-position of adenine was found to exhibit potent IFN inducing activity in vivo. Compound 9o induced IFN from the dosage of 0.1 mg/kg, which was 30-fold potent than that of Imiquimod, and showed a good oral bioavailability (F=81%).

Heterocyclic compounds

The present invention relates to a heterocyclic compound of the following general formula (I): wherein X is sulfur atom, oxygen atom or —NR3— (R3may form a heterocyclic ring or a substituted heterocyclic ring with R1via the nitrogen atom), R1is alkyl group, substituted alkyl group, aryl group, substituted aryl group, heterocyclic group or substituted heterocyclic group, and R2is hydrogen atom, halogen atom etc.; or its pharmaceutically acceptable salt and interferon inducers, antiviral agents, anticancer agents and therapeutic agents for immunologic diseases comprising the compound (I) or its pharmaceutically acceptable salt as active ingredients.