226908-43-6

Basic information

• Product Name: 8H-Purin-8-one, 2,6-diamino-7,9-dihydro-9-(phenylmethyl)-
• CAS NO: 226908-43-6
• Molecular Formula: C12H12N6O
• Molecular Weight: 256.267
• Mol File: 226908-43-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 8H-Purin-8-one, 2,6-diamino-7,9-dihydro-9-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 8H-Purin-8-one, 2,6-diamino-7,9-dihydro-9-(phenylmethyl)-(226908-43-6)
• EPA Substance Registry System: 8H-Purin-8-one, 2,6-diamino-7,9-dihydro-9-(phenylmethyl)-(226908-43-6)

Safety Data

• Hazardous Substances Data: 226908-43-6(Hazardous Substances Data)

Upstream product

• 226908-04-9 2,6-diamino-9-benzyl-8-bromopurine 
• 100-46-9 benzylamine 
• 3173-56-6 benzyl isothiocyanate 
• 5451-40-1 2,6 dichloropurine 
• 1839-18-5 2-chloroadenine 
• 17356-08-0 thiourea 
• 226908-19-6 5-amino-1-benzyl-4-cyano-2-hydroxyimidazole 
• 50-01-1 guanidine hydrochloride 
• 7674-36-4 9-Benzylpurine-2,6-diamine 

Relevant articles and documents

Efficient synthesis of 2,9-disubstituted 8-hydroxyadenine derivatives

An efficient and general method for the synthesis of 2,9-disubstituted 8-hydroxyadenines, which are expected to have various biological activities, was realized. 5-amino-4-cyano-2-hydroxyimidazoles(1) were prepared from aminomalononitrile and isocyanates as key intermediates. The condensation of 1a with amidines, imidates, guanidine, urea and thioureas afforded 8-hydroxyadenines (2-6) possessing various substituents at the 2-position. Furthermore, selective alkylation of 2-amino- and 2-hydroxyadenines (4 and 6) successively proceeded to give the corresponding 2-alkylamino- and 2-alkoxyadenines (5 and 7), respectively. 2-Alkythioadenines (15) were prepared by an analogous reaction of 1a with benzoyl isothiocyanate and subsequent S-alkylation. The imidazoles 1 are most useful intermediated for the synthesis of 8-hydroxyadenine derivatives.

Novel and efficient synthesis of 8-oxoadenine derivatives

A novel synthetic method of 8-oxoadenine derivatives (3 and 4) is reported. This widely applicable synthetic method was realized through the use of 5-amino-4-cyano-2-oxoimidazole derivatives (2) as the key intermediates. A variety of substituents were successfully introduced to the 2- and 9-position of the 8-oxoadenine nucleus.