227184-11-4

Basic information

• Product Name: 6-(1-FLUOROETHYL)-4(1H)-PYRIMIDINONE
• Synonyms: 6-(1-FLUOROETHYL)-4(1H)-PYRIMIDINONE;4(1H)-Pyrimidinone, 6-(1-fluoroethyl)- (9CI)
• CAS NO: 227184-11-4
• Molecular Formula: C6H7FN2O
• Molecular Weight: 142.13
• Product Categories: PYRIMIDINE;Pyrimidine series
• Mol File: 227184-11-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-(1-FLUOROETHYL)-4(1H)-PYRIMIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(1-FLUOROETHYL)-4(1H)-PYRIMIDINONE(227184-11-4)
• EPA Substance Registry System: 6-(1-FLUOROETHYL)-4(1H)-PYRIMIDINONE(227184-11-4)

Safety Data

• Hazardous Substances Data: 227184-11-4(Hazardous Substances Data)

Usage

General Description

6-(1-fluoroethyl)-4(1H)-pyrimidinone is an organic chemical compound with the chemical formula C6H7FN2O. It is a pyrimidinone derivative with a fluorine-containing ethyl group attached to the sixth carbon in the pyrimidinone ring. 6-(1-FLUOROETHYL)-4(1H)-PYRIMIDINONE is commonly used in pharmaceutical research and drug development as a building block for the synthesis of various bioactive molecules and pharmaceuticals. Its unique structural features and reactivity make it a valuable intermediate in organic synthesis, particularly in the development of potential drug candidates for various therapeutic applications. Furthermore, its fluorine-containing moiety makes it an important functional group for the development of fluorinated pharmaceuticals, which often exhibit improved properties and biological activity compared to non-fluorinated analogs.

Upstream product

• 227183-98-4 4-fluoro-methyl-3-oxopentanoate 
• 3473-63-0 formamidine acetic acid 
• 227184-02-3 ethyl α-fluoropropionylacetate 

Downstream Products

• 438449-92-4 6-(1-fluoroethyl)-5-iodo-4-pyrimidone 

Relevant articles and documents

4-fluoro-3-oxocarboxylic esters and process for producing the same

The present invention is to provide 4-fluoro-3-oxocarboxylates represented by the following formula (1): wherein R1represents an alkyl group or an aryl group; R2and R3each represent a hydrogen atom or an alkyl group; and R4represents an alkyl group, and a process for preparing a 4-fluoro-3-oxocarboxylate represented by the above formula (1), which comprises allowing a 2-fluorocarboxylate represented by the following formula (2): wherein R1and R2have the same meanings as defined above; and R5represents an alkyl group, to react with a carboxylate represented by the following formula (3): wherein R3and R4have the same meanings as defined above, in the presence of a base.

6-(1-fluoroalkyl)-4-pyrimidones and processes for producing the same

The present invention is to provide a novel 6-(1-fluoroalkyl)-4-pyrimidone represented by the following formula (1): wherein R1represents an alkyl group; R2represents a hydrogen atom or an alkyl group; and R3represents a hydrogen atom, an alkyl group or a chlorine atom, which is important for a synthetic intermediate for aminopyrimidine derivatives which are useful as acaricides, fungicides or nematocides, and processes for producing the same.