227449-41-4

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 2-(methylthio)-4-[[3-(trifluoromethyl)phenyl]amino]-
• CAS NO: 227449-41-4
• Molecular Formula: C13H10F3N3O2S
• Molecular Weight: 329.303
• Mol File: 227449-41-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 2-(methylthio)-4-[[3-(trifluoromethyl)phenyl]amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 2-(methylthio)-4-[[3-(trifluoromethyl)phenyl]amino]-(227449-41-4)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 2-(methylthio)-4-[[3-(trifluoromethyl)phenyl]amino]-(227449-41-4)

Safety Data

• Hazardous Substances Data: 227449-41-4(Hazardous Substances Data)

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 5909-24-0 4-chloro-2-methanesulfanylpyrimidine-5-carboxylic acid ethyl ester 
• 3859-55-0 ethyl 2-methylsulfanyl-4-(3-trifluoromethylanilino)pyrimidine-5-carboxylate 

Downstream Products

• 863029-02-1 N-methyl-2-methylsulfanyl-4-(3-trifluoromethylanilino)pyrimidine-5-carboxamide 
• 863029-03-2 N,N-dimethyl-2-methylsulfanyl-4-(3-trifluoromethylanilino)pyrimidine-5-carboxamide 
• 227449-63-0 2-methylsulfanyl-4-(3-trifluoromethylanilino)pyrimidine-5-carboxamide 

Relevant articles and documents

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives

Spleen tyrosine kinase (Syk) is a non-receptor-type tyrosine kinase which mediates diverse responses in haematopoietic cells. Therefore, Syk is an attractive therapeutic target, and in a study of Syk inhibitors as potentially new therapeutic agents, we di