227783-08-6 Usage
Description
(1R,3S)-1,3-Cyclohexanedicarboxylic Acid 1-Ethylester is an organic compound with the molecular formula C10H16O4. It is a chiral molecule with specific stereochemistry at the first and third carbon atoms, denoted by the (1R,3S) configuration. (1R,3S)-1,3-Cyclohexanedicarboxylic Acid 1-Ethylester is characterized by its ester functional group, which is derived from the reaction of the corresponding dicarboxylic acid with an alcohol, in this case, ethanol.
Uses
Used in Pharmaceutical Industry:
(1R,3S)-1,3-Cyclohexanedicarboxylic Acid 1-Ethylester is used as a key intermediate in the synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase. This enzyme plays a crucial role in the fungal pathogen's survival and virulence, making it a promising target for the development of new antifungal agents. The compound's unique stereochemistry and functional groups contribute to its effectiveness in this application, potentially leading to the creation of novel therapeutics for the treatment of Candida-related infections.
Check Digit Verification of cas no
The CAS Registry Mumber 227783-08-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,7,7,8 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 227783-08:
(8*2)+(7*2)+(6*7)+(5*7)+(4*8)+(3*3)+(2*0)+(1*8)=156
156 % 10 = 6
So 227783-08-6 is a valid CAS Registry Number.
227783-08-6Relevant articles and documents
Development of a Scalable Synthesis of an Azaindolyl-Pyrimidine Inhibitor of Influenza Virus Replication
Liang, Jianglin,Cochran, John E.,Dorsch, Warren A.,Davies, Ioana,Clark, Michael P.
, p. 965 - 969 (2016/06/09)
A scalable, asymmetric route for the synthesis of the influenza virus replication inhibitor 2 is presented. The key steps include an enzymatic desymmetrization of cis-1,3-cyclohexanediester in 99% yield and 96% ee, SNAr displacement of a methanesulfinylpyrimidine, and a Curtius rearrangement to form a morpholinyl urea. This high-yielding route allowed us to rapidly synthesize hundreds of grams of 2 in 99% purity to support in vivo studies.
Stereoselective process for preparing cylcohexyl amine derivatives
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Page 18, (2010/02/05)
A process for preparing (1R,3S)-3-(9-chloro-3-methyl-4-oxo-5H-(isoxazoloquinolin-5-yl))cyclohexanecarboxylic acid and esters thereof, as represented by formulas II and III, wherein R is a lower alkyl groups, and A and B are N or O, provided that when A is N, B is O, or when A is O, B is N: Formula (III) and Formula (II).
Enzymatic desymmetrization of cis-1,3-cyclohexanedicarboxylic acid diesters
Boaz, Neil W.
, p. 813 - 816 (2007/10/03)
cis-1,3-Cyclohexanedicarboxylic acid (1,3-CHDA) monoesters were prepared in high overall yield and high enantiomeric purity using a three step process from cis/trans-1,3-CHDA. The asymmetry is induced by an enzymatic hydrolytic desymmetrization of a meso
