227803-33-0

Basic information

• Product Name: 5-CHLORO-2-(PHENYLMETHYL)-INDOLE
• Synonyms: 5-CHLORO-2-(PHENYLMETHYL)-INDOLE;5-CHLORO-2-(PHENYLMETHYL)-1H-INDOLE
• CAS NO: 227803-33-0
• Molecular Formula: C₁₅H₁₂ClN
• Molecular Weight: 241.72
• Mol File: 227803-33-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 412.6 °C at 760 mmHg
• Flash Point: 235.7 °C
• Appearance: /
• Density: 1.25 g/cm³
• Vapor Pressure: 1.22E-06mmHg at 25°C
• Refractive Index: 1.676
• CAS DataBase Reference: 5-CHLORO-2-(PHENYLMETHYL)-INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-(PHENYLMETHYL)-INDOLE(227803-33-0)
• EPA Substance Registry System: 5-CHLORO-2-(PHENYLMETHYL)-INDOLE(227803-33-0)

Safety Data

• Hazardous Substances Data: 227803-33-0(Hazardous Substances Data)

Usage

General Description

5-CHLORO-2-(PHENYLMETHYL)-INDOLE is a chemical compound with the formula C16H18ClN. It is an indole derivative with a chloro substitution at the 5th position and a phenylmethyl group attached to the 2nd position of the indole ring. 5-CHLORO-2-(PHENYLMETHYL)-INDOLE has potential applications in pharmaceutical research, particularly in the development of novel drugs targeting serotonin receptors. Its unique structure and pharmacological properties make it a promising candidate for further studies in the field of medicinal chemistry and drug discovery. Additionally, it may also have uses in other industrial applications, such as in the synthesis of organic compounds and materials.

InChI:InChI=1/C15H12ClN/c16-13-6-7-15-12(9-13)10-14(17-15)8-11-4-2-1-3-5-11/h1-7,9-10,17H,8H2

Upstream product

• 932-98-9 1-chloro-4-nitroso-benzene 
• 81784-69-2 N-Hydroxy-3-oxo-4,N-diphenyl-butyramide 
• 92433-38-0 1-benzyl-5-chloro-1H-indole 
• 4436-24-2 1,2-epoxy-3-phenylpropane 
• 106-47-8 4-chloro-aniline 
• 17422-32-1 5-chloro-1H-indole 
• 100-39-0 benzyl bromide 

Downstream Products

• 936243-82-2 2-benzyl-5-chloro-3-nitro-1H-indole 
• 936243-89-9 2-benzyl-5-chloro-1H-indol-3-ylamine 
• 936244-01-8 N,N'-bis-Boc-N''-(2-benzyl-5-chloro-1H-indol-3-yl)guanidine 

Relevant articles and documents

Efficient synthesis of 3-(4,5-dihydro-1H-imidazole-2-yl)-1H-indoles

A simple method for the synthesis of various 3-(4,5-dihydro-1H-imidazole-2-yl)-1H-indoles is described. Treatment of different substituted indoles with 1-acetyl-imidazolidin-2-one in the presence of phosphorus oxychloride afforded after hydrolysis in etha

Ruthenium-catalyzed regioselective synthesis of 2-substituted indoles via ring-opening of epoxides by anilines

Anilines react with epoxides in dioxane at 180°C in the presence of a catalytic amount of a ruthenium catalyst along with tin(II) chloride to afford 2-substituted indoles in moderate to good yields.

New route to 2-substituted indoles by pyrolysis of N-acylacetylphenylhydroxylamines

Convenient and regiospecific synthesis of 2-substituted indol (3) by thermolysis of N-acylacetylphenylhydroxylamine (1) and its mechanism including the formation of a radical intermediate are reported.