22817-11-4

Basic information

• Product Name: Benzeneethanol, a-(2-methylphenyl)-
• CAS NO: 22817-11-4
• Molecular Formula: C15H16O
• Molecular Weight: 212.291
• Mol File: 22817-11-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzeneethanol, a-(2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanol, a-(2-methylphenyl)-(22817-11-4)
• EPA Substance Registry System: Benzeneethanol, a-(2-methylphenyl)-(22817-11-4)

Safety Data

• Hazardous Substances Data: 22817-11-4(Hazardous Substances Data)

Upstream product

• 87100-28-5 pinacol benzylboronate 
• 529-20-4 2-methylphenyl aldehyde 
• 96-09-3 styrene oxide 
• 16419-60-6 2-Methylphenylboronic acid 
• 6921-34-2 benzylmagnesium chloride 
• 122-78-1 phenylacetaldehyde 
• 100-39-0 benzyl bromide 

Downstream Products

• 16216-13-0 2-phenyl-1-o-tolylethanone 
• 16619-12-8 2-phenyl-indan-1-one 
• 799804-26-5 2-mesyloxy-1-(2-methylphenyl)-2-phenyl-ethanone 
• 74942-20-4 2-bromo-2-phenyl-1-(o-tolyl)ethanone 
• 74942-21-5 2-amino-5-phenyl-4-(o-tolyl)thiazole 
• 74942-22-6 5-phenyl4-(o-tolyl)thiazole 
• 129448-69-7 1-(2-methylphenyl)-2-phenyl-3-(3-methoxyphenyl)-1-propanone 

Relevant articles and documents

Chemoselective Benzylation of Aldehydes Using Lewis Base Activated Boronate Nucleophiles

A benzylation of aldehydes using primary and secondary benzylboronic acid pinacol esters is reported. Activation of the boronic ester with s-butyllithium rendered it nucleophilic toward aldehydes. The activated nucleophile chemoselectively transfers the benzyl group over the sec-butyl group, providing excellent yields of the benzylated products. 11B NMR experiments were performed to study the mechanism of this transformation.

COMPOUNDS

The present invention describes non-cyclic enaminoketone compounds and their applications relating to absorption electromagnetic energy, in particular UV radiation.

Synthetic method for diaryl-substituted ethanol compound serving as medical intermediate

The invention relates to a synthetic method for a diaryl-substituted ethanol compound serving as a medical intermediate shown as a formula (III). The method comprises the following steps: reacting a compound shown as a formula (I) and a compound shown as a formula (II) in a hermetic way in an organic solvent in the presence of a catalyst and an alkali; performing posttreatment at the end of the reaction to obtain a compound shown as the formula (III), wherein R1 and R2 are independently selected from H, alkyl with 1-6 carbon atoms, alkoxy with 1-6 carbon atoms or halogen; or R2 and a benzene ring which is connected with the R2 form a naphthalene ring. According to the synthetic method, the diaryl-substituted ethanol compound can be obtained at a high yield through comprehensive selection and coordination of a specific reaction substrate, the catalyst, the alkali and the organic solvent, and has good application prospect and industrial production potential in the field of synthesis of medical intermediates.