228859-13-0

Basic information

• Product Name: {4-[(6-hydroxy-naphthalen-2-yl)-imino-methylcarbamoyloxymethyl]-phenoxy}-acetic acid allyl ester
• Synonyms: {4-[(6-hydroxy-naphthalen-2-yl)-imino-methylcarbamoyloxymethyl]-phenoxy}-acetic acid allyl ester
• CAS NO: 228859-13-0
• Molecular Weight: 434.448
• Mol File: 228859-13-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {4-[(6-hydroxy-naphthalen-2-yl)-imino-methylcarbamoyloxymethyl]-phenoxy}-acetic acid allyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {4-[(6-hydroxy-naphthalen-2-yl)-imino-methylcarbamoyloxymethyl]-phenoxy}-acetic acid allyl ester(228859-13-0)
• EPA Substance Registry System: {4-[(6-hydroxy-naphthalen-2-yl)-imino-methylcarbamoyloxymethyl]-phenoxy}-acetic acid allyl ester(228859-13-0)

Safety Data

• Hazardous Substances Data: 228859-13-0(Hazardous Substances Data)

Upstream product

• 2916-14-5 allyl chloroacetate 
• 58200-88-7 6-Amidino-2-naphthol 
• 192064-31-6 4-nitrophenyl-4'-hydroxymethylphenyl-1'-oxyallylacetate carbonate 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 58200-88-7 6-Amidino-2-naphthol 

Relevant articles and documents

Inhibition of the tissue factor/factor VIIa complex - Lead optimisation using combinatorial chemistry

Following a high throughput screen (HTS) for the inhibition of the tissue factor/factor VIIa complex and the identification of a number of original hits a lead optimisation programme was initiated to improve their potency. This necessitated the development of an amidine based linker which allowed the generation of a library of amidinonaphthols prepared both by multiple parallel synthesis (MPS) and split and mix methods. The most active compound had an IC50 of 4μM some 10x more potent than the original lead compound.