228869-37-2

Basic information

• Product Name: 3-Benzyloxy-N,N-diethyl-2-formyl-4-methoxy-benzamide
• Synonyms: 3-Benzyloxy-N,N-diethyl-2-formyl-4-methoxy-benzamide
• CAS NO: 228869-37-2
• Molecular Weight: 341.407
• Mol File: 228869-37-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-Benzyloxy-N,N-diethyl-2-formyl-4-methoxy-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Benzyloxy-N,N-diethyl-2-formyl-4-methoxy-benzamide(228869-37-2)
• EPA Substance Registry System: 3-Benzyloxy-N,N-diethyl-2-formyl-4-methoxy-benzamide(228869-37-2)

Safety Data

• Hazardous Substances Data: 228869-37-2(Hazardous Substances Data)

Upstream product

• 598-30-1 sec.-butyllithium 
• 228869-36-1 3-benzyloxy-N,N-diethyl-4-methoxy-benzamide 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 41222-60-0 3-benzyloxy-4-methoxybenzoyl chloride 
• 58452-00-9 3-benzyloxy-4-methoxybenzoic acid 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 256421-77-9 5-benzyloxy-6-methoxy-2H-phthalazin-1-one 
• 256443-15-9 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-5-(5-phenyl-pent-1-ynyl)-phthalazine 
• 228869-42-9 6-methoxy-5-(5-phenyl-pentyloxy)-2H-phthalazin-1-one 
• 256443-86-4 6-methoxy-5-(5-phenyl-pent-1-ynyl)-2H-phthalazin-1-one 
• 256443-87-5 1-Chloro-6-methoxy-5-(5-phenyl-pent-1-ynyl)-phthalazine 

Relevant articles and documents

Phthalazine derivatives as phosphodiesterase 4 inhibitors

Compounds of formula (I) wherein B is alkylene, amino, CONH or a bond; Cy is optionally substituted phenyl or heteroaryl; R is H, phenyl or (C1-4)alkyl optionally substituted; R1is (C1-6)alkyl or polyfluoro(C1-6)-alkyl; R2is (C4-7)cycloalkyl optionally containing an oxygen atom and optionally substituted; and the N→O derivatives and pharmaceutically acceptable salt thereof are PDE 4 and TNFα inhibitors.

Phthalazine derivatives phosphodiesterase 4 inhibitors

The present invention provides a compound selected from the group including: 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-phenyl-phthalazine; 4-(3,5-dichloro-pyridin-4-ylmethyl)-7-methoxy-1H-phthalazin-2-carboxylic acid methyl ester; benzyl-{3-{1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-phthalazin-5-yl}-prop-2-ynyl}-methyl-amine; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-5-(5-morpholin-4-yl-pent-1-ynyl)-phthalazine dihydrochloride; 3-{1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-phthalazin-5-yl}-prop-2-yn-1-ol; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-morpholin-4-yl-phthalazine; 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-4-(1,2,4)triazol-1-yl-phthalazine; N→O derivatives thereof; and pharmaceutically acceptable salts thereof. The invention also provides a pharmaceutical composition which includes a therapeutically effective amount of the above compound in admixture with a suitable carrier.