22897-99-0

Basic information

• Product Name: (3-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER
• Synonyms: (3-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER;Ethyl-3-trifluoromethylphenoxyacetate, 98 %;Ethyl-3-trifluoromethylphenoxyacetate;Ethyl-3-trifluoromethylphenoxyacetate, min.
• CAS NO: 22897-99-0
• Molecular Formula: C₁₁H₁₁F₃O₃
• Molecular Weight: 248.2
• Mol File: 22897-99-0.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 123°C/14mmHg(lit.)
• Appearance: /
• Density: 1.241±0.06 g/cm3(Predicted)
• Refractive Index: 1.4530 to 1.4570
• CAS DataBase Reference: (3-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (3-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER(22897-99-0)
• EPA Substance Registry System: (3-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER(22897-99-0)

Safety Data

• Hazardous Substances Data: 22897-99-0(Hazardous Substances Data)

Usage

General Description

(3-Trifluoromethylphenoxy) acetic acid ethyl ester is a chemical compound with the molecular formula C10H9F3O3. It is a fluoroaromatic compound and an ethyl ester of (3-trifluoromethylphenoxy) acetic acid. (3-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER is commonly used as a building block in organic synthesis and may be used in pharmaceutical research and development. It is also used as an intermediate in the production of agrochemicals and other fine chemicals. Additionally, it has potential applications in the field of materials science and as a reagent in chemical analysis.

Upstream product

• 336625-15-1 ethyl (2-iodo-5-trifluoromethyl-phenoxy)acetate 
• 98-17-9 3-Trifluoromethylphenol 
• 105-36-2 ethyl bromoacetate 
• 102771-00-6 2-iodo-5-(trifluoromethyl)phenol 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 696577-43-2 N-(2-Benzylamino-ethyl)-2-(3-trifluoromethyl-phenoxy)-acetamide 
• 63212-89-5 (3-trifluoromethylphenoxy)acetaldehyde 
• 349-82-6 (3-trifluoromethylphenoxy)acetic acid 
• 88462-67-3 4-(m-trifluoromethylphenoxy)-3-trimethylsilyloxy-1-butyne 
• 88462-65-1 (+/-)-4-[(3-trifluoromethyl)phenoxy]-1-butyne-3-ol 
• 85630-83-7 <(m-trifluoromethyl)phenoxy>acetyl chloride 
• 826990-62-9 3-cyano-2-methyl-6-trifluoromethyl-benzofuran 
• 826990-52-7 [(3-trifluoromethylphenoxyacetyl)(cyano)methylene]triphenylphosphorane 
• 54094-19-8 dimethyl [3-(3-(trifluoromethyl)phenoxy)-2-oxopropyl]phosphonate 
• 1395103-24-8 2-[(3-trifluoromethylphenoxy)acetoxy](furan-2-yl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1395103-29-3 2-(3-trifluoromethylphenoxyacetoxy)(phenyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 1395103-35-1 2-(3-trifluoromethylphenoxyacetoxy)(methyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one 
• 904702-76-7 O-methyl [(2-(3-trifluoromethylphenoxy)acetoxy)(2,4-dichlorophenyl)methyl]methylphosphinate 
• 904702-77-8 O-methyl [(2-(3-trifluoromethylphenoxy)acetoxy)(2-chlorophenyl)methyl]methylphosphinate 

Relevant articles and documents

Synthesis and larvicidal activity of 1,3,4-oxadiazole derivatives containing a 3-chloropyridin-2-yl-1H-pyrazole scaffold

Abstract: A new series of 1,3,4-oxadiazole derivatives with a 3-chloropyridin-2-yl-1H-pyrazole moiety was designed, synthesized, and characterized. The results of bioassay against Helicoverpa armigera and Plutella xylostella indicated that some of the synthesized compounds showed remarkable larvicidal activity. In particular, the LC50 values of the most active compounds against P. xylostella were 46.5, 23.9, and 13.9?mg/dm3, and against Helicoverpa armigera were 88.3 and 69.5?mg/dm3, the latter being slightly better than commercial chlorpyrifos (LC50 103.77?mg/dm3). Preliminary SAR was also discussed. Graphical abstract: [Figure not available: see fulltext.].

Synthesis and biological activity of 1-(Substituted phenoxyacetoxy)- 1-(pyridin-2-yl or thien-2-yl)methylphosphonates

A series of novel O,O-dimethyl 1-(substituted phenoxyacetoxy)-1-(pyridin-2-yl or thien-2-yl)methylphosphonates 6a-n and 7a-d were synthesized. Their structures were confirmed by IR, 1H NMR, mass spectroscopy, and elemental analyses. The results of preliminary bioassays show that some of the title compounds exhibit moderate to good herbicidal and fungicidal activities. For example, the title compounds 6a, 6c, 6l, 6m, and 7d possess 90-100% inhibition against most of the tested plants at the dosage of 1500 g ai/ha, whereas the title compounds 6b, 6g-h and 6n possess 92-100% inhibition against Fusarium oxysporum, Phyricularia grisea, Botrytis cinereapers, Gibberella zeae, Sclerotinia sclerotiorum, and Cercospora beticola at the concentration of 50mg/L.

Synthesis and herbicidal activity of 2-(substituted phenoxyacetoxy)alkyl-5, 5-dimethyl-1,3,2-dioxaphosphinan-2-one containing fluorine

A series of novel 2-(substituted phenoxyacetoxy)alkyl-5,5-dimethyl-1,3,2- dioxaphosphinan-2-one bearing fluorine 5a-n and fluorine free 5o-q were designed and synthesized. The results of bioassay showed that some of the target compounds exhibited excellent herbicidal activities to Abutilon theophrasti, Brassica juncea, Amaranthus retroflexus and Eclipta prostrata in post-emergence treatment at a dosage of 150 g ai/ha. It could be found that the type and position of fluorine-containing group as X or Y on benzene ring had a very important effect on herbicidal activity. Compound 5l 2-[(2-chloro-4- fluorophenoxy)acetoxy](methyl)methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one showed notable herbicidal activity, with 100% inhibition against A. theophrasti and A. retroflexus; and compound 5m 2-(3-trifluoromethylphenoxyacetoxy)(methyl) methyl-5,5-dimethyl-1,3,2-dioxaphosphinan-2-one with 100% inhibition against A. theophrasti even at a dosage of 75 g ai/ha. Additional crop selectivity testing showed that compounds 5g 2-(3-trifluoromethylphenoxyacetoxy)(phenyl)methyl-5,5- dimethyl-1,3,2-dioxaphosphinan-2-one and 5l are safe to rice, corn, cotton, rape and wheat.