229178-74-9

Basic information

• Product Name: Benzoic acid,2,6-difluoro-3-iodo-
• Synonyms: 2,6-Difluoro-3-iodobenzoicacid
• CAS NO: 229178-74-9
• Molecular Formula: C₇H₃F₂IO₂
• Molecular Weight: 283.9988
• Mol File: 229178-74-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 311.1°C at 760 mmHg
• Flash Point: 142°C
• Appearance: /
• Density: 2.144g/cm³
• Vapor Pressure: 0.000247mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.99±0.10(Predicted)
• CAS DataBase Reference: Benzoic acid,2,6-difluoro-3-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid,2,6-difluoro-3-iodo-(229178-74-9)
• EPA Substance Registry System: Benzoic acid,2,6-difluoro-3-iodo-(229178-74-9)

Safety Data

• Hazardous Substances Data: 229178-74-9(Hazardous Substances Data)

Usage

General Description

Benzoic acid, 2,6-difluoro-3-iodo-, is a chemical compound with the molecular formula C7H4F2IO2. It is a derivative of benzoic acid, with two fluorine atoms and one iodine atom attached to the benzene ring. Benzoic acid,2,6-difluoro-3-iodo- is commonly used in organic synthesis and can be used as a building block for the preparation of various pharmaceuticals and agrochemicals. It has also been studied for its potential antimicrobial and anti-inflammatory properties. Additionally, it can be used as a reagent in chemical reactions and is often employed in the production of fine chemicals.

InChI:InChI=1/C7H3F2IO2/c8-3-1-2-4(10)6(9)5(3)7(11)12/h1-2H,(H,11,12)

Upstream product

• 385-00-2 2,6-difluorobenzoic acid 
• 501433-14-3 methyl 2,6-difluoro-3-iodobenzoate 
• 124-38-9 carbon dioxide 
• 13697-89-7 2,6-difluoroiodobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 2265-92-1 1,4-difluoro-2-iodobenzene 
• 501432-99-1 1,4-difluoro-2,3-diiodobenzene 

Downstream Products

• 229178-75-0 2,6-difluoro-3-iodobenzamide 
• 229178-76-1 2,6-difluoro-3-[2-(ethoxycarbonyl)vinyl]benzamide 
• 229178-77-2 2,6-difluoro-[2-(ethoxycarbonyl)ethyl]benzamide 
• 229178-79-4 1-[4-(2-chloro-α,α,α-trifluoro-4-tolyloxy)-2-fluorophenyl]-3-[2,6-difluoro-3-(2-carbonylethyl)benzoyl]urea 
• 229178-78-3 1-[4-(2-chloro-α,α,α-trifluoro-4-tolyloxy)-2-fluorophenyl]-3-[2,6-difluoro-3-(2-ethoxycarbonylethyl)benzoyl]urea 
• 501433-14-3 methyl 2,6-difluoro-3-iodobenzoate 
• 1333140-87-6 methyl 3-(3-chloro-2-fluorobenzyl)-2,6-difluorobenzoate 
• 1333140-88-7 3-(3-chloro-2-fluorobenzyl)-2,6-difluorobenzoic acid 
• 1333140-89-8 methyl 3-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorophenyl)-3-oxopropanoate 
• 1333140-90-1 methyl 2-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorobenzoyl)-3-(dimethylamino)acrylate 
• 1333141-21-1 C₂₁H₁₉ClF₃NO₃ 
• 1333141-22-2 C₂₂H₂₁ClF₃NO₃ 
• 1333141-23-3 C₂₃H₂₃ClF₃NO₃ 
• 1333141-24-4 C₂₁H₁₉ClF₃NO₃ 

Relevant articles and documents

Structural modifications of quinolone-3-carboxylic acids with anti-HIV activity

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This study describes immunochemical approaches for the compound-specific detection of flufenoxuron and class-specific detection of benzoylphenylurea (BPU) insecticides. With the aim of developing a highly specific immunoassay for flufenoxuron, a hapten was synthesized by introducing a spacer arm at the 2,6-difluoro substituent aromatic ring of a flufenoxuron derivative. An IC50 value of 2.4 ppb was obtained for flufenoxuron, with detection of the other four BPUs being more than 4000-fold less sensitive. For the development of class-specific ELISA for five BPUs, a new approach was used for the hapten preparation in which a butanoic acid linkage was introduced into the 3,5- dichlorosubstitued aniline ring of chlorfluazuron analogue. Although the resultant ELISA still exhibited slightly differing cross-reactions for these five BPUs, this method had broader specificity than the previously reported polyclonal antibody-based ELISA. Spike and recovery studies for five BPUs in soil and water indicated that both the compound- and class-specific ELISAs were able to quantitatively detect BPU residues in soil and water. This study also provided additional insights into the influence of the immunizing hapten structure on the specificities of the antibodies obtained.