22990-77-8 Usage
Description
2-Piperidinemethanamine, also known as 2-(Methylamino)piperidine, is an organic compound with the molecular formula C6H12N2. It is a heterocyclic amine derivative of piperidine, featuring a secondary amine functional group. This versatile compound serves as a key building block in the synthesis of various pharmaceuticals and chemical compounds due to its unique structural properties and reactivity.
Uses
Used in Pharmaceutical Synthesis:
2-Piperidinemethanamine is used as a reactant in the synthesis of compounds exhibiting anti-osteoclast and anti-osteoblast activity. These compounds are essential in the development of treatments for bone-related disorders, such as osteoporosis and bone metastasis in cancer patients.
Additionally, 2-Piperidinemethanamine is used in the synthesis of potent antibacterial agents, contributing to the development of new antibiotics to combat drug-resistant bacterial infections.
Used in Chemical Synthesis:
2-Piperidinemethanamine serves as a reactant for reversible aminal formation, a crucial step in the synthesis of various organic compounds and materials.
It is also used as a reactant in the synthesis of annulated N-heterocyclic carbene ligands, which are important in catalysis and coordination chemistry.
Furthermore, 2-Piperidinemethanamine is employed in the synthesis of M3 Muscarinic receptor antagonists, a class of drugs that target the M3 muscarinic receptor and have potential applications in the treatment of overactive bladder, chronic obstructive pulmonary disease (COPD), and other conditions.
2-Piperidinemethanamine is also used in the synthesis of selective 5-HT5A receptor antagonists, which have potential therapeutic applications in the treatment of psychiatric and neurological disorders, such as schizophrenia, anxiety, and depression.
Lastly, it is used in the synthesis of ternary platinum(II) complexes, which are of interest in the field of coordination chemistry and have potential applications in catalysis and medicinal chemistry.
Purification Methods
Dry (over Na2SO4) and distil the piperidine under vacuum from KOH. It has been purified via the Reinekate salt (m 173-174o) and its dipicrate salt (m 201o, from H2O). [Norton et al. J Am Chem Soc 68 1330 1946, Mortimer Aust J Chem 11 84 1958, Augustine J Am Chem Soc 81 4667 1959, Beilstein 22 III/IV 3765.]
Check Digit Verification of cas no
The CAS Registry Mumber 22990-77-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,9,9 and 0 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 22990-77:
(7*2)+(6*2)+(5*9)+(4*9)+(3*0)+(2*7)+(1*7)=128
128 % 10 = 8
So 22990-77-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H14N2/c7-5-6-3-1-2-4-8-6/h6,8H,1-5,7H2
22990-77-8Relevant articles and documents
Process for the preparation of 2-aminomethylpiperidine
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Page/Page column 1, (2008/12/07)
The invention relates to a process for the preparation of aminomethylpyridines of the general formula (I) by hydrogenation of cyanopyridines of the general formula (II) with hydrogen under increased pressure optionally in the presence of a catalyst containing Ni, Fe or Co and optionally in the presence of ammonia.
Preparation of esters of phosphorus acids
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, (2008/06/13)
Esters of phosphorus acids are prepared by an improved process whereby aromatic alcohols and phosphorus halides are reacted at specified temperatures in the presence of amine catalysts thereby providing high yields of substantially pure esters and allowing preparation of selected halogen-containing mono- and di-esters of phosphorus acids wherein halogen is directly bonded to phosphorus having substantially no side reactant contamination. The phosphorus esters are useful as intermediates in the preparation of plasticizers, oil additives and functional fluids.
