57415-44-8

Basic information

• Product Name: Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monohydrochloride
• Synonyms: flecainide hydrochloride;2,5-bis(2,2,2-trifluoroethoxy)-N-(2-piperidylmethyl)benzamide hydrochloride
• CAS NO: 57415-44-8
• Molecular Formula: C17H20F6N2O3.ClH
• Molecular Weight: 450.80400
• Mol File: 57415-44-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monohydrochloride(57415-44-8)
• EPA Substance Registry System: Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monohydrochloride(57415-44-8)

Safety Data

• Hazardous Substances Data: 57415-44-8(Hazardous Substances Data)

Upstream product

• 22990-77-8 C-piperidin-2-yl-methylamine 
• 50778-57-9 2,2,2-trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate 
• 7440-44-0 pyrographite 
• 54143-55-4 flecainide 

Relevant articles and documents

Production method of flecainide

The invention belongs to the technical field of compound synthesis, and particularly relates to a production method of flecainide, which comprises the following steps: 1) etherification reaction, 2) acetylation reaction, 3) oxidation reaction and 4) refining. According to the production method, qualified flecainide is synthesized through three steps, the process steps are simplified, the process operation is simple, the etherification reaction, the acetylation reaction and the oxidation reaction are adopted, so that the flecainide yield is stable, the yield is high, the impurity separation iseasily achieved, and the impurity operation is simple and convenient.

Antiarrhythmic method utilizing fluoroalkoxy-N-piperidyl and pyridyl benzamides

Certain compounds in which a carbon atom of a pyrrolidine or piperidine ring is bonded directly or through a methylene group to the nitrogen of a substituted benzamido group, and their pharmaceutically acceptable salts, are found to be active as antiarrhythmic agents.