2302-84-3

Basic information

• Product Name: 1-formylthiosemicarbazide
• Synonyms: 1-formylthiosemicarbazide;FORMYL THIOSEMICARBAZID;1-Formyl-3-thiosemicarbazide, 97%;BRN 1753835;Formic acid 2-(aminothioxomethyl) hydrazide;N'-(Thiocarbamoyl)formhydrazide;2-formylhydrazinecarbothioamide;Hydrazinecarbothioamide, 1-formyl-
• CAS NO: 2302-84-3
• Molecular Formula: C₂H₅N₃OS
• Molecular Weight: 119.1456
• EINECS: 218-955-9
• Mol File: 2302-84-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 227.6°Cat760mmHg
• Flash Point: 91.5°C
• Appearance: /
• Density: 1.399g/cm³
• Vapor Pressure: 0.0767mmHg at 25°C
• Refractive Index: 1.6100 (rough estimate)
• CAS DataBase Reference: 1-formylthiosemicarbazide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-formylthiosemicarbazide(2302-84-3)
• EPA Substance Registry System: 1-formylthiosemicarbazide(2302-84-3)

Safety Data

• Hazardous Substances Data: 2302-84-3(Hazardous Substances Data)

Usage

General Description

1-formylthiosemicarbazide, also known as 4-Formylthiosemicarbazide, is a chemical compound with the molecular formula CH4N4OS. It is a yellow to brown crystalline solid that is soluble in water and ethanol. 1-formylthiosemicarbazide is commonly used as a reagent in chemical reactions to form various derivatives and compounds. It is also utilized in the synthesis of other organic compounds and as a starting material for the preparation of semicarbazones. This chemical has applications in the pharmaceutical and chemical industries, particularly in the production of insecticides and herbicides. Additionally, 1-formylthiosemicarbazide has shown potential pharmacological activity and is being researched for its antimicrobial and anticancer properties. Overall, 1-formylthiosemicarbazide is a versatile chemical that plays a significant role in various industrial and scientific applications.

InChI:InChI=1/C2H5N3OS/c3-2(7)5-4-1-6/h1H,(H,4,6)(H3,3,5,7)

Upstream product

• 64-18-6 formic acid 
• 79-19-6 thiosemicarbazide 
• 2258-42-6 formyl acetic anhydride 
• 2565-30-2 formyl chloride 
• 3129-90-6 isothiocyanic acid 
• 624-84-0 formic acid hydrazide 

Downstream Products

• 3179-31-5 2,3-dihydro-1H-1,2,4-triazole-3-thione 
• 4005-51-0 [1,3,4]Thiadiazol-2-ylamin 
• 5393-55-5 2-acetylamino-1,3,4-thiadiazole 
• 26861-87-0 [1,3,4]thiadiazol-2-ylamine; hydrochloride 
• 46503-03-1 formic acid N'-(4-amino-5-phenyl-thiazol-2-yl)-hydrazide 
• 3179-31-5 1H-1,2,4-triazole-5-thiol 
• 3775-60-8 1,3,4-oxadiazol-2-amine 
• 3179-31-5 3-mercapto-1,2,4-triazole 
• 3179-31-5 1H-[1,2,4]triazole-3-thiol 
• 3179-31-5 2,4-dihydro-[1,2,4]triazole-3-thione 

Relevant articles and documents

Synthesis, characterization and anti-inflammatory activity evaluation of 1,2,4-triazole and its derivatives as a potential scaffold for the synthesis of drugs against prostaglandin-endoperoxide synthase

Substituted 1,2,4-triazole nucleus is common in several drugs used in a variety of clinical conditions including infections, hypoglycemia, hypertension and cancer. In this study, we synthesized 1,2,4-triazole and its 16 hydrazone derivatives (B1–B16), characterized them by IR, NMR and Mass spectroscopy, and evaluated their radical scavenging and anti-inflammatory activities in?vitro and in?vivo. Out of 16 derivatives, five (B1, B5, B6, B9, and B13) demonstrated a significant radical scavenging and anti-inflammatory activity in?vitro. B6, which possessed two electron-donating hydroxyl groups, was most active among all. Molecular docking and MD simulation of the complex of B6 with prostaglandin-endoperoxide synthase (PTGS) or cyclooxygenase (COX) showed that B6 occupied celecoxib binding site in COX with high affinity (the binding free energy of the complex with COX-1 was –10.5, and –11.2 kcal/mol with COX-2). Maximum anti-inflammatory activity was also shown by the B6 derivative in?vivo, in the rat model of carrageenan-induced inflammation. B6, along with four other derivatives (B1, B5, B9 and B13) exhibited 80–90% free radical scavenging activity. The IC50 values of these compounds were ≥40 μM. Griess nitrite and dichloro-dihydro-fluorescein-diacetate assays suggested a significant inhibition of nitric oxide and reactive oxygen species, especially by B6 and B9. Taken together, out of 16 derivatives, B6 is reported to have highest anti-inflammatory and antioxidant activity at a low dose level, which may be attributed to its two electron-donating hydroxyls. B6 is proposed to be an important scaffold for the synthesis of new drugs against PTGS for use in a myriad of inflammatory and infectious diseases. Communicated by Ramaswamy H. Sarma.

HETEROCYCLIC AMIDE COMPOUND

PROBLEM TO BE SOLVED: To provide a heterocyclic amide compound useful as an active ingredient of a herbicide. SOLUTION: The present disclosure provides a heterocyclic amide compound represented by the following formula or a salt thereof. Q-N(R3)-C(=X)-W (Q: a substituted/unsubstituted 1,3,4-oxadiazole, 1,2,5-oxadiazole or the like. W: a substituted/unsubstituted [1,2,4]triazolo[4,3-a]pyridine or the like. X: O, S. R3: H, C1-C6 alkyl or the like). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Design, Synthesis, and Structure-Activity Relationship of Economical Triazole Sulfonamide Aryl Derivatives with High Fungicidal Activity

Plant fungal diseases have caused great decreases in crop quality and yield. As one of the considerable agricultural diseases, cucumber downy mildew (CDM) caused by pseudoperonospora cubensis seriously influences the production of cucumber. Amisulbrom is a commercial agricultural fungicide developed by Nissan Chemical, Ltd., for the control of oomycetes diseases that is highly effective against CDM. However, the synthesis of amisulbrom has a high cost because of the introduction of the bromoindole ring. In addition, the continuous use of amisulbrom might increase the risk of resistance development. Hence, there is an imperative to develop active fungicides with new scaffolds but low cost against CDM. In this study, a series of 1,2,4-triazole-1,3-disulfonamide derivatives were designed, synthesized, and screened. Compound 1j showed a comparable fungicidal activity with amisulbrom, but it was low cost and ecofriendly. It has the potential to be developed as a new fungicide candidate against CDM. Further investigations of structure-activity relationship exhibited the structural requirements of 1,2,4-triazole-1,3-disulfonamide and appropriate modification in N-alkyl benzylamine groups with high fungicidal activity. This research will provide powerful guidance for the design of highly active lead compounds with a novel skeleton and low cost.