2306252-57-1

Basic information

• Product Name: 2,7-diazaspiro[4.4]-nonane-2-carboxylic acid tert-butyl ester
• CAS NO: 2306252-57-1
• Molecular Weight: 226.319
• Mol File: 2306252-57-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,7-diazaspiro[4.4]-nonane-2-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,7-diazaspiro[4.4]-nonane-2-carboxylic acid tert-butyl ester(2306252-57-1)
• EPA Substance Registry System: 2,7-diazaspiro[4.4]-nonane-2-carboxylic acid tert-butyl ester(2306252-57-1)

Safety Data

• Hazardous Substances Data: 2306252-57-1(Hazardous Substances Data)

Usage

Molecular structure

A complex molecular structure with a spirocyclic compound containing a diazabicyclo[2.2.1]heptane core.

Functional groups

Contains a carboxylic acid and a tert-butyl ester functional group attached.

Usage

Commonly used as a building block in organic synthesis.

Application in pharmaceuticals

Utilized in the production of pharmaceuticals.

Application in agrochemicals

Involved in the creation of agrochemicals.

Potential in medicinal chemistry

Serves as a precursor in the synthesis of bioactive compounds.

Relevance to materials science

May have uses in materials science due to its unique structural and electronic properties.

Upstream product

• 77480-26-3 2,7-diazaspiro[4.4]nonane 
• 1433194-62-7 2,7-di(tert-butyloxycarbonyl)-2,7-diazaspiro[4.4]nonane 
• 885275-27-4 2-benzyl 2,7-diaza-spiro-[4.4]nonane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1177266-41-9 tert-butyl 7-benzyl-2,7-diazaspiro[4.4]nonane-2-carboxylate 

Downstream Products

• 1392889-10-9 C₂₄H₃₀N₈S 
• 1392889-25-6 C₂₉H₃₈N₈O₂S 
• 1181354-58-4 phenyl(2,7-diazaspiro[4.4]nonan-2-yl)methanone 
• 1426437-10-6 1-(4-fluoro-7-(1H-1,2,3-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(7-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonan-2-yl)ethane-1,2-dione 
• 1426437-19-5 2-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane 
• 1426437-14-0 C₂₅H₂₂FN₇O₃ 
• 1426437-18-4 tert-butyl 7-(1-phenyl-1H-tetrazol-5-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate 
• 1426437-20-8 tert-butyl 7-benzoyl-2,7-diazaspiro[4.4]nonane-2-carboxylate 
• 885275-24-1 2-phenyl-2,7-diazaspiro[4.4]nonane 

Relevant articles and documents

Synthesis and differential functionalisation of pyrrolidine and piperidine based spirodiamine scaffolds

The synthesis and differential substitution/protection of a series of spirodiamine scaffolds are described. Methods for selective access to the two mono-N-methyl isomers based on 2,7-diazaspiro[4.5]decane are also described. Key precursors associated with this chemistry are prone to rearrangement and methods for circumventing this issue are reported. While direct mono-carbamoylation (Boc) was not efficient, selective deprotection of doubly Boc-protected derivatives derived from symmetrical diamines provided mono-Boc variants. N-Arylation, exemplified by a series of monosubstituted spirodiamines incorporating the 2-chloro-5-pyridyl moiety, which is a privileged nicotinic agonist substructure, has also been carried out to provide monoarylated secondary and tertiary spirodiamines variants.

Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors

Several N-pyridin-3-yl spirobicyclic diamines, designed as conformationally restricted analogs of tebanicline (ABT-594), were synthesized as novel ligands for nicotinic acetylcholine receptors (nAChR). The spirocyclic compounds exhibited weaker binding affinity, than other constrained analogs in accord with a pharmacophore model. Nevertheless, some (1a, 1b) possessed (partial) agonist potencies comparable to nicotine at the α4β2 subtype, but with greatly improved selectivity relative to the α3β4* nAChR.