23275-37-8Relevant articles and documents
Simple route to chiral organophosphorus compounds
Kolodiazhnyi, Oleg I.,Grishkun, Evgen V.
, p. 967 - 970 (1996)
Reaction of chlorides of nonsymmetrically substituted phosphinic and phosphinous acid with (-)-1,2,3,5-disubstituted-α-D-glucofuranose proceeds with very high stereoselectivity to give stereochemically pure phosphinic and phosphinous acid esters, which are starting reagents for preparation of chiral organophosphorus compounds. Stereoselectivity of the reaction depends on the nature of bases, solvent, temperatures and excess of chlorophosphine.
METHOD FOR ENANTIOSELECTIVE SYNTHESIS OF PHOSPHORUS-STEREOGENIC PHOSPHINES
-
Page/Page column 37-38, (2008/06/13)
The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.
SYNTHESE DIRECTE DE PHOSPHINES TERTIARIES RACEMIQUES ET DE CHLOROPHOSPHINES DISSYMETRIQUES
Chodkiewicz, W.,Guillerm, D.,Jore, D.,Mathieu, E.,Wodzki, W.
, p. 107 - 114 (2007/10/02)
Racemic tertiary phosphines are obtained from dichlorophenylphosphine by a "one pot" synthesis in two steps: (1) condensation of one equivalent of an organocadmium, and (2) substitution of the second chlorine by another organometallic compound.The phosphines liberated from the resulting complexes can be stabilised by direct complexation with cuprous salts.The monochlorophosphines can be isolated in the first stage when their cadmium complexes are submitted to ligand exchange with pyridine.