232951-83-6

Basic information

• Product Name: tert-Butyl 2-chloronicotinate
• Synonyms: tert-Butyl 2-chloronicotinate;2-Chloro-nicotinic acid tert-butyl ester;tert-Butyl 2-chloro-3-pyridinecarboxylate;tert-butyl 2-chloropyridine-3-carboxylate
• CAS NO: 232951-83-6
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.66078
• Mol File: 232951-83-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 275.6±20.0 °C(Predicted)
• Appearance: /
• Density: 1.173±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -1.48±0.10(Predicted)
• CAS DataBase Reference: tert-Butyl 2-chloronicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 2-chloronicotinate(232951-83-6)
• EPA Substance Registry System: tert-Butyl 2-chloronicotinate(232951-83-6)

Safety Data

• Hazardous Substances Data: 232951-83-6(Hazardous Substances Data)

Usage

General Description

Tert-Butyl 2-chloronicotinate, also known as TBNC, is a chemical compound that belongs to the class of nicotinate esters. It is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. TBNC is a white crystalline solid with a molecular weight of 209.67 g/mol and a melting point of 105-107°C. It is soluble in organic solvents such as methanol, ethanol, acetone, and chloroform. TBNC is known for its potential applications in the field of medicinal chemistry, particularly in the development of drugs for the treatment of various diseases. It is also used in the production of insecticides and herbicides due to its effective pesticidal properties. Additionally, it is widely utilized in the research and development of new chemical entities in the pharmaceutical and agricultural industries.

Upstream product

• 49609-84-9 2-Chloronicotinoyl chloride 
• 865-47-4 potassium tert-butylate 
• 2942-59-8 2-chloronicotinic acid 
• 75-65-0 tert-butyl alcohol 
• 121495-79-2 2-chloropyridine-3-carbonyl chloride hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 464216-16-8 tert-butyl 2-aminopyridine-3-carboxylate 

Downstream Products

• 338990-70-8 tert-butyl 2-(methylamino)pyridine-3-carboxylate 
• 32399-12-5 2-(N-methylamino)-3-hydroxymethylpyridine 
• 338990-31-1 N-methyl N-(3-[((N-tert-butoxycarbonyl-N-methylamino)acetoxy)methyl]pyridin-2-yl)carbamic acid (1-chloroethyl) ester 
• 338990-63-9 1-[[N-methyl-N-3-[(t-butoxycarbonylmethylamino)acetoxymethyl]pyridin-2-yl]carbamoyloxy]ethyl-1-[(2R,3R)-2-(2,5-difluorophenyl)-2-hydroxy-3-[4-(4-cyanophenyl)thiazol-2-yl]butyl]-1H-[1,2,4]triazol-4-ium chloride 
• 232951-19-8 5-(S)-Acetamidomethyl-3-[4'-(5-carboxypyridine-3-yl)thio-3'-fluorophenyl]-oxazolidine-2-one 
• 1399035-74-5 tert-butyl 2-phenylnicotinate 
• 1403480-29-4 tert-butyl((2R,3R)-2-((tert-butyldimethylsilyl)oxy)-4-(N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2-((2S)-pent-4-en-2-yloxy)nicotinamido)-3-methylbutyl)(methyl)carbamate 
• 1403479-44-6 N-(((8R,9R,15S)-6-((2S)-1-aminopropan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide 
• 1403480-54-5 tert-butyl ((2R,3R)-2-hydroxy-4-(N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2-((2S)-pent-4-en-2-yloxy)nicotinamido)-3-methylbutyl)carbamate 
• 1403480-72-7 tert-butyl ((2R,3R)-2-(allyloxy)-4-(N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2-((2S)-pent-4-en-2-yloxy)nicotinamido)-3-methylbutyl)carbamate 
• 1403481-51-5 tert-butyl (((8R,9R,15S)-6-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-8,15-dimethyl-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)(methyl)carbamate 
• 1403479-46-8 N-(((8R,9R,15S)-8,15-dimethyl-6-((2S)-1-(methylamino)propan-2-yl)-5-oxo-5,6,7,8,9,11,12,13,14,15-decahydropyrido[2,3-b][1,9,5]dioxaazacyclotetradecin-9-yl)methyl)-4-fluoro-N-methylbenzenesulfonamide 

Relevant articles and documents

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The present invention provides a production method of heterocyclic compound having an excellent CH24H inhibitory action, which is suitable for industrial production. In the present invention, a 2-halogenonicotinic acid or a reactive derivative thereof or a salt thereof is reacted with 4-benzyl-4-hydroxypiperidine acid addition salt to give a (4-benzyl-4-hydroxypiperidin-1-yl) (2-halogenopyridin-3-yl)methanone or a salt thereof, and then the obtained compound is reacted with pyridine-4-boronic acid or a reactive derivative thereof or a salt thereof in the presence of a metal catalyst and a base to give (4-benzyl-4-hydroxypiperidin-1-yl) (2,4′-bipyridin-3-yl)methanone or a salt thereof.